Peer-reviewed veterinary case report
Biomarkers linked to elbow osteoarthritis from fragmented coronoid
By Hurlbeck, C et al.·Published in Research in veterinary science·2014·Tierklinik Dresdner Heide, Germany·View original on PubMed →
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Original publication title: Evaluation of biomarkers for osteoarthritis caused by fragmented medial coronoid process in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with elbow joint pain due to a condition called fragmented medial coronoid process (FMCP) had their joint fluid tested to see if certain markers could indicate cartilage damage. The tests showed that dogs with FMCP had higher levels of specific enzymes in their joint fluid, which could help vets assess the severity of the arthritis. This research suggests that these markers might be useful for diagnosing osteoarthritis in dogs with this condition.
People also search for: dog elbow pain treatment · fragmented medial coronoid process in dogs · osteoarthritis biomarkers in dogs
Abstract
The aim of the present work was to evaluate whether concentrations of the carboxy-terminal cross-linked fragment of type II collagen (CTX-II), the activities of matrix metalloproteinase-2 and -9 (MMP-2/-9) and Myeloperoxidase (MPO) in canine synovial fluids (SF) can reflect structural alterations of articular cartilage in dogs with fragmented medial coronoid process (FMCP). Elbow joints with FMCP underwent radiographic and arthroscopic examination. Commercially available assays were used to analyze SF for CTX-II concentration and MMP-2/-9 activity. MPO activity was measured by o-dianisidine-assay. The MMPs were further evaluated by zymography. CTX-II concentration and MMP-2 activity showed age-dependent trends in controls. Increased enzyme activities of MPO and MMP-2/-9 were found in diseased dogs. MMP-9activity seems suitable to underline the subjective assessment of the degree of cartilage damage. These initial data of the study suggest that MPO and MMP-2/9 may be used as objective biomarkers in the diagnosis of canine osteoarthritis due to FMCP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24684895/