Peer-reviewed veterinary case report
Genetic study finds no cause for short-limbed chondrodysplasia
By Smit, Jelke Jan et al.·Published in Veterinary journal (London, England : 1997)·2011·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Evaluation of candidate genes as a cause of chondrodysplasia in Labrador retrievers.
- Species:
- dog
Plain-English summary
A group of Labrador Retrievers with short limbs was found to have chondrodysplasia, a hereditary condition that affects their mobility. Researchers looked at the genetics of 13 affected dogs from eight litters to understand how the disease was passed down. They examined several candidate genes but found that none were directly linked to the condition. This suggests that while chondrodysplasia is inherited, the specific genes involved may not be among those tested.
People also search for: Labrador chondrodysplasia symptoms · short limbs in Labradors · genetic testing for Labrador diseases
Abstract
Chondrodysplasia (CD) is a disabling, hereditary disease in Labradors with short limbs, warranting genetic screening in families at risk. Segregation analysis of eight litters with 13 affected dogs showed that autosomal recessive inheritance was consistent with the observed incidence of CD in the litters. Possible involvement of eight candidate collagen genes (COL9A1, COL9A2, COL9A3, COMP, MATN3, COL2A1, COL11A1 and COL11A2) and of a sulfate transporter glycoprotein (SLC26A2) gene in eight affected dogs and in 14 related control Labradors was investigated. Assuming recessive inheritance, the candidate genes could not be implicated in CD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20018534/