Peer-reviewed veterinary case report
HSF4 gene not linked to cataracts in English Cocker Spaniels
By Engelhardt, A et al.·Published in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie·2007·Institute for Animal Breeding and Genetics, Germany·View original on PubMed →
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Original publication title: Evaluation of canine heat-shock transcription factor 4 as a candidate for primary cataracts in English Cocker Spaniels and wire-haired Kromfohrlanders.
- Species:
- dog
Plain-English summary
A study looked at whether a specific gene mutation was linked to cataracts in English Cocker Spaniels and wire-haired Kromfohrlanders. Researchers examined the HSF4 gene but did not find the mutation that causes cataracts in other breeds. They also tested another genetic variation but found no significant connection to cataracts in these breeds. This means that the gene mutation they studied is not responsible for primary cataracts in English Cocker Spaniels and wire-haired Kromfohrlanders.
People also search for: English Cocker Spaniel cataracts · dog eye problems · Kromfohrlander cataract treatment
Abstract
Canine heat-shock transcription factor 4 (HSF4) was evaluated as a candidate for primary cataracts in English Cocker Spaniels (ECS) and wire-haired Kromfohrlanders (KFL). We sequenced exon 9 and its flanking regions of the HSF4 gene in ECS and KFL but were not able to detect a previously reported insertion mutation associated with primary cataracts in Staffordshire Bull Terriers and Boston Terriers. Another single nucleotide polymorphism (LOC489766:g.3243A>G) in intron 9 was identified and included in linkage and association tests together with two flanking microsatellites. Linkage and association tests with primary cataracts in ECS and KFL were not significant. Therefore, we could not verify that the mutation in exon 9 of canine HSF4 gene is causative for primary cataracts in ECS and wire-haired KFL.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17651328/