Peer-reviewed veterinary case report
Can stem cells help dogs recover from brain injuries?
By Jiang, Wenkang et al.·Published in BMC veterinary research·2024·Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, China·View original on PubMed →
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Original publication title: Evaluation of canine adipose-derived mesenchymal stem cells for neurological functional recovery in a rat model of traumatic brain injury.
- Species:
- dog
Plain-English summary
This study looked at how stem cells taken from fat tissue in dogs might help with recovery from traumatic brain injury (TBI) in rats. The researchers found that these canine stem cells helped improve nerve function and reduced cell death in the brain, as well as lowering inflammation caused by certain brain cells. They discovered that the stem cells encouraged a type of brain cell to become less inflammatory, which could help with healing. Overall, the findings suggest that using these canine stem cells could be a promising treatment for TBI in dogs, as they seem to support recovery and reduce harmful inflammation.
Abstract
BACKGROUND: Traumatic brain injury (TBI) is a common condition in veterinary medicine that is difficult to manage.Veterinary regenerative therapy based on adipose mesenchymal stem cells seem to be an effective strategy for the treatment of traumatic brain injury. In this study, we evaluated therapeutic efficacy of canine Adipose-derived mesenchymal stem cells (AD-MSCs)in a rat TBI model, in terms of improved nerve function and anti-neuroinflammation. RESULTS: Canine AD-MSCs promoted neural functional recovery, reduced neuronal apoptosis, and inhibited the activation of microglia and astrocytes in TBI rats. According to the results in vivo, we further investigated the regulatory mechanism of AD-MSCs on activated microglia by co-culture in vitro. Finally, we found that canine AD-MSCs promoted their polarization to the M2 phenotype, and inhibited their polarization to the M1 phenotype. What's more, AD-MSCs could reduce the migration, proliferation and Inflammatory cytokines of activated microglia, which is able to inhibit inflammation in the central system. CONCLUSIONS: Collectively, the present study demonstrates that transplantation of canine AD-MSCs can promote functional recovery in TBI rats via inhibition of neuronal apoptosis, glial cell activation and central system inflammation, thus providing a theoretical basis for canine AD-MSCs therapy for TBI in veterinary clinic.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38500105/