Peer-reviewed veterinary case report
Blood markers linked to lung fibrosis risk in healthy West Highland
By Roels, E et al.·Published in Research in veterinary science·2015·Department of Clinical Sciences·View original on PubMed →
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Original publication title: Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with variable predisposition for canine idiopathic pulmonary fibrosis.
- Species:
- dog
Plain-English summary
A group of healthy West Highland White Terriers (WHWT) was found to have higher levels of a specific protein called CXCL8 compared to other dog breeds, which may explain their increased risk for a lung disease known as canine idiopathic pulmonary fibrosis (CIPF). Additionally, the WHWT and Maltese breeds showed higher levels of another protein, CCL2, compared to King Charles Spaniels and Belgian Malinois. However, the study did not find significant differences in serotonin levels among the breeds. These findings suggest that certain blood markers could help identify dogs at risk for this lung condition, especially in breeds like the WHWT.
People also search for: West Highland White Terrier lung disease · canine idiopathic pulmonary fibrosis symptoms · high CXCL8 levels in dogs
Abstract
The West Highland white terrier (WHWT) is particularly prone to canine idiopathic pulmonary fibrosis (CIPF). We hypothesized that higher circulating concentrations of chemokines CXCL8, CCL2, serotonin (5-HT), or vascular endothelial growth factor (VEGF) could serve as predisposing factors for CIPF development in the WHWT breed. Serum samples from 103 healthy dogs of seven different breeds variably predisposed to CIPF were collected. Serum CXCL8 concentrations were higher in healthy WHWT compared with each of the other groups of healthy dogs. Serum CCL2 concentrations were higher in healthy WHWT and Maltese compared with King Charles spaniels and Malinois Belgian shepherds. No relevant inter-breed differences were observed for serum 5-HT concentrations regarding CIPF predisposition. VEGF values from 89.3% of samples tested were below the kit detection limit. In conclusion, high CXCL8 blood concentrations and possibly CCL2 concentrations might be related to the breed predisposition of the WHWT for CIPF and warrants further investigations.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26267090/