Peer-reviewed veterinary case report
Blood test for IGF-I and IGFBP-3 to detect tumors in dogs
By Song, Doo-Won et al.·Published in Journal of veterinary science·2021·College of Veterinary Medicine, South Korea·View original on PubMed →
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Original publication title: Evaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogs.
- Species:
- dog
Plain-English summary
A study looked at blood levels of certain proteins in dogs to see if they could help detect tumors. Researchers found that dogs with tumors had higher levels of IGF-I and lower levels of IGFBP-3 compared to healthy dogs. This means that measuring these proteins in the blood could potentially help veterinarians diagnose cancer in dogs. While this research is promising, it's important to talk to your vet about the best ways to check for tumors in your pet.
People also search for: dog cancer symptoms · how to detect tumors in dogs · IGF-I levels in dogs · IGFBP-3 and dog tumors
Abstract
BACKGROUND: Serum-based parameters are considered non-invasive biomarkers for cancer detection. In human studies, insulin-like growth factor-I and II (IGF-I and IGF-II) and insulin-like growth factor binding protein-3 (IGFBP-3) are useful as diagnostic or prognostic markers and potential therapeutic targets. OBJECTIVES: This study examined the diagnostic utility of circulating IGF-I, IGF-II, and IGFBP-3 levels in healthy dogs and dogs with tumors. METHODS: The serum concentrations of these biomarkers in 86 dogs with tumors were compared with those in 30 healthy dogs using an enzyme-linked immunosorbent assay (ELISA). RESULTS: The ELISA results showed no difference between healthy dogs and dogs with tumors in the serum IGF-II concentrations. On the other hand, there was a significant difference in the circulating IGF-I and IGFBP-3 levels between healthy dogs and dogs with tumors. The concentrations of serum IGF-I (median [interquartile range], 103.4 [59.5-175] ng/mL) in dogs with epithelial tumors were higher than those (58.4 ng/mL [43.5-79.9]) in healthy dogs. Thus, the concentrations of serum IGFBP-3 (43.4 ng/mL [33.2-57.2]) in dogs with malignant mesenchymal tumors were lower than those (60.8 ng/mL [47.6-70.5]) in healthy dogs. CONCLUSIONS: The serum IGF-I and IGFBP-3 levels can be used as diagnostic biomarkers in dogs with tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34697923/