Peer-reviewed veterinary case report
MicroRNA changes in dogs with acute pancreatic injury after cerulein
By Lee, Han-Byul et al.·Published in International journal of molecular sciences·2018·Asan Institute for Life Sciences, South Korea·View original on PubMed →
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Original publication title: Evaluation of Circulating MicroRNA Biomarkers in the Acute Pancreatic Injury Dog Model.
- Species:
- dog
Plain-English summary
A group of dogs with induced acute pancreatitis showed increased levels of specific microRNAs (miR-216a and miR-375) that could help detect the severity of their condition. These microRNAs rose significantly after treatment and correlated well with the damage seen in their pancreas. While traditional blood tests for enzymes also increased, the changes in these microRNAs were more pronounced and could provide a more sensitive measure of pancreatic injury. This research suggests that monitoring miR-216a and miR-375 could be beneficial for diagnosing and assessing pancreatitis in dogs.
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Abstract
This study aimed to evaluate the usefulness of four microRNAs (miRNAs) in an acute pancreatic injury dog model. Acute pancreatitis was induced by infusion of cerulein for 2 h (7.5 μg/kg/h). The levels of well-known miRNAs, microRNA-216a (miR-216a) and microRNA-375 (miR-375), and new candidates microRNA-551b (miR-551b), and microRNA-7 (miR-7), were measured at 0, 0.5, 1, 2, 6, 12, and 24 h with serum amylase and lipase, and histopathological examination was performed. Among the four miRNAs, miR-216a and miR-375, and serum enzymes were significantly increased by cerulein treatment. The expression levels of miRNAs and serum enzymes peaked at 2⁻6 h with a similar pattern; however, the overall increases in miR-216a and miR-375 levels were much higher than those of the serum enzyme biomarkers. Increased levels of miR-216a and miR-375 were most highly correlated to the degree of individual histopathological injuries of the pancreas, and showed much greater dynamic response than serum enzyme biomarkers. Twenty-four-hour time-course analysis in this study revealed time-dependent changes of miRNA expression levels, from initial increase to decrease by predose level in acute pancreatitis. Our findings demonstrate that, in dogs, miR-216a and miR-375 have the potential to sensitively detect pancreatitis and reflect well the degree of pancreatic injury, whereas miR-551b and miR-7 do not.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30301227/