Peer-reviewed veterinary case report
Treatment effects on vomiting and diarrhea in dogs
By García-Sancho, M et al.·Published in Journal of veterinary internal medicine·2007·Department of Animal Medicine and Surgery, Spain·View original on PubMed →
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Original publication title: Evaluation of clinical, macroscopic, and histopathologic response to treatment in nonhypoproteinemic dogs with lymphocytic-plasmacytic enteritis.
- Species:
- dog
Plain-English summary
A group of 16 dogs with chronic vomiting and diarrhea due to lymphocytic-plasmacytic enteritis (LPE) were treated with medications including prednisone and metronidazole. Over 120 days, most dogs showed improvement in their symptoms and endoscopic findings, with 75% having better results in their stomach and intestine after treatment. However, the underlying tissue damage did not change significantly. Overall, the treatment helped reduce vomiting and diarrhea, making the dogs feel better, even though the microscopic issues remained the same.
People also search for: dog vomiting treatment · lymphocytic-plasmacytic enteritis in dogs · prednisone for dog diarrhea
Abstract
BACKGROUND: Lymphocytic-plasmacytic enteritis (LPE) is a common cause of chronic vomiting and diarrhea in dogs. However, little information is available about endoscopic or histopathologic improvement after therapy in dogs with LPE. HYPOTHESIS: The objective was to study the clinical, endoscopic, and histopathologic evolution of LPE during and after immunosuppressive treatment with prednisone and metronidazole. Most dogs also were treated symptomatically with metoclopramide and cimetidine. ANIMALS: Sixteen dogs with LPE and normal serum protein concentrations diagnosed at the Veterinary Medical Teaching Hospital of the Complutense University of Madrid were monitored during and after drug treatment. The control group consisted of 9 dogs that had no gastrointestinal signs for the preceding 12 months. METHODS: In this prospective clinical treatment trial, clinical, endoscopic, and histopathologic scores were evaluated to describe disease evolution during conventional therapy. Dogs with LPE were monitored for 120 days from the start of treatment. Re-evaluation was performed on post-treatment days 30, 60, 90 (end of treatment), and 120. RESULTS: The average disease activity index observed in our study fell progressively from its initial value, and the decrease between consecutive re-evaluations was statistically significant until day 60 (P = .04). Our results indicate that 75% of the animals revealed improvement of endoscopic gastric lesions (defined as a reduction of the endoscopic score) after treatment, and 75% exhibited improvement of endoscopic duodenal lesions. Statistical analysis of the data revealed significant differences between pre- and post-treatment gastric and duodenal macroscopic endoscopic lesions (P < .05). On the other hand, treatment did not lead to any significant changes in the severity of the gastric and duodenal histopathologic lesions of the affected dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Treatment of nonhypoproteinemic dogs with LPE led to clinical and endoscopic improvement, but histopathologic lesions were unchanged during therapy.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17338144/