Peer-reviewed veterinary case report
Blood clotting problems in dogs with gallbladder mucoceles
By Pavlick, Michelle et al.·Published in Journal of veterinary internal medicine·2021·Cummings School of Veterinary Medicine at Tufts University, United States·View original on PubMed →
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Original publication title: Evaluation of coagulation parameters in dogs with gallbladder mucoceles.
- Species:
- dog
Plain-English summary
A group of 23 dogs with gallbladder mucoceles (a condition where the gallbladder fills with mucus) were studied to understand their blood clotting status. Most of these dogs showed signs of hypercoagulability, meaning their blood was more prone to clotting than normal. Tests revealed increased levels of certain proteins and platelets, indicating a complex issue with their blood's ability to clot properly. While the dogs had these coagulation changes, there was no clear link between the severity of their gallbladder condition and the blood test results. It's important for pet owners to be aware of these potential complications when dealing with gallbladder issues in dogs.
People also search for: dog gallbladder mucocele symptoms · dog blood clotting issues · gallbladder disease in dogs treatment
Abstract
BACKGROUND: Gallbladder mucocele (GBM) is a common biliary disorder in dogs. Limited information is available on the coagulation status of dogs with GBM. HYPOTHESIS/OBJECTIVES: To determine patterns of coagulation alterations in dogs with GBM and correlate them with clinicopathologic abnormalities and ultrasonographic findings of disease severity. ANIMALS: Twenty-three dogs with GBM identified on ultrasound examination were prospectively enrolled. METHODS: At the time of GBM identification, blood and urine were collected for CBC, serum biochemical panel, urinalysis, prothrombin time, activated partial thromboplastin time (aPTT), factor VIII, protein C (PC), von Willebrand's factor (vWF), antithrombin activity, fibrinogen, D-dimers, and thromboelastrography (TEG). Gallbladder mucoceles were classified into ultrasound types 1 to 5. Medical records were reviewed for clinical presentation, underlying conditions and to determine if systemic inflammatory response syndrome (SIRS) was present. RESULTS: Based on TEG parameters, maximal amplitude, and G, 19/23 (83%) of dogs with GBM had evaluations consistent with hypercoagulability. On plasma-based coagulation testing, dogs with GBM had increased total PC activity (20/23, 87%), fibrinogen (9/23, 39%), platelet count (9/23, 39%), and D-dimers (6/15, 40%) as well as prolongations in aPTT (9/22, 41%) and low vWF activity (5/21, 24%). No correlation was found between TEG G value and any coagulation or clinical pathology variables, ultrasound stage of GBM or disease severity as assessed by the presence of SIRS. CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with ultrasonographically identified GBM have changes in whole blood kaolin-activated TEG supporting a hypercoagulable state although traditional plasma-based coagulation testing suggests that a complex state of hemostasis exists.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34196054/