Peer-reviewed veterinary case report
COMMD1 gene role in copper poisoning in Labradors and Dobermans
By Wu, Xiaoyan et al.·Published in Veterinary journal (London, England : 1997)·2020·Department of Clinical Sciences, Netherlands·View original on PubMed →
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Original publication title: Evaluation of COMMD1 in copper toxicosis in Labrador retrievers and Dobermans.
- Species:
- dog
Plain-English summary
A study looked at copper toxicosis, a serious liver condition, in Labrador retrievers and Dobermans. Researchers examined the DNA of 30 dogs from each breed to see if changes in a specific gene (COMMD1) were linked to liver copper levels. They found several genetic variations, but none were connected to the copper levels in these dogs. This suggests that COMMD1 is not a major factor in causing liver problems related to copper in these breeds.
People also search for: dog copper toxicosis symptoms · Labrador retriever liver disease · Doberman copper levels testing
Abstract
Copper toxicosis is a major cause of hepatitis in dogs. We have shown that variants in ATP7A and ATP7B modulate hepatic copper levels in Labrador retrievers and Dobermans. However, these variants cannot fully explain the observed variation in hepatic copper levels in these dog breeds. Homozygous deletion of exon 2 of COMMD1 causes copper toxicosis in Bedlington terriers. We investigated the possible involvement of COMMD1 in the multifactorial aetiology of copper toxicosis in Labrador retrievers and Dobermans. Thirty dogs of each breed with known hepatic copper status were selected for DNA sequence analysis of the three exons and flanking intronic regions of COMMD1. The observed variants were tested for association with hepatic copper levels by linear model analysis. Several variants were observed in the DNA sequence of COMMD1 in both Labrador retrievers (nine variants) and Dobermans (11 variants) but none of these was associated with variations of hepatic copper concentrations. We conclude that COMMD1 did not play a major role in the aetiology of copper associated hepatitis in Labrador retrievers and Dobermans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33129558/