Peer-reviewed veterinary case report
Blood test signs of inflammation in dogs with mouth tumors or gum
By Rejec, Ana et al.·Published in Journal of veterinary dentistry·2017·1 Animal Hospital Postojna·View original on PubMed →
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Original publication title: Evaluation of Complete Blood Count Indices (NLR, PLR, MPV/PLT, and PLCRi) in Healthy Dogs, Dogs With Periodontitis, and Dogs With Oropharyngeal Tumors as Potential Biomarkers of Systemic Inflammatory Response.
- Species:
- dog
Plain-English summary
A study looked at blood test results from dogs with gum disease (periodontitis) and those with throat tumors (oropharyngeal tumors) compared to healthy dogs. The researchers found that certain blood markers, specifically the neutrophil to lymphocyte ratio (NLR) and platelet large cell ratio index (PLCRi), were significantly higher in dogs with tumors, suggesting they might indicate an inflammatory response related to cancer. However, there were no significant changes in blood markers for dogs with gum disease. More research is needed to confirm these findings and their usefulness in diagnosing health issues in dogs.
People also search for: dog blood test results · dog gum disease symptoms · oropharyngeal tumor in dogs · dog cancer blood markers
Abstract
The aim of the study was to retrospectively assess complete blood count (CBC) indices of dogs with periodontitis (PD; n = 73) and dogs with oropharyngeal tumors (OT; n = 92) in comparison to CBC indices of healthy dogs (HD; n = 71). Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, mean platelet volume to platelet ratio, and platelet large cell ratio index (PLCRi) were evaluated as biomarkers of systemic inflammatory response provoked by PD and OT. Results of multivariable polytomous logistic regression analysis indicated no significant associations between CBC indices and PD. Both NLR and PLCRi were significantly higher in dogs with OT when compared to HD and dogs with PD and could, therefore, indicate a tumor-associated systemic inflammatory response. Additional studies of CBC indices, along with other biomarkers of systemic inflammatory response, are recommended to validate them as reliable indicators of clinical disease activity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28936913/