Peer-reviewed veterinary case report
Accuracy of compounded trilostane packets for dogs
By Nam, Sookin et al.·Published in Journal of veterinary internal medicine·2021·College of Veterinary Medicine, South Korea·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of compounded trilostane packets for dogs with naturally occurring hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of dogs with naturally occurring hyperadrenocorticism (a hormonal disorder) in Korea was given compounded packets of trilostane, a medication used to manage this condition. However, tests showed that only about 41% of these packets contained the correct amount of the drug, which could affect how well the dogs respond to treatment. This suggests that pet owners and veterinarians should be cautious about the accuracy of compounded medications for managing hyperadrenocorticism. Ensuring the right dosage is crucial for effective treatment.
People also search for: dog hyperadrenocorticism treatment · trilostane dosage for dogs · compounded medications for dogs
Abstract
BACKGROUND: Dogs treated for naturally occurring hyperadrenocorticism (NOH) in Korea often appear to require higher doses of trilostane than recommended by authors in the United States, Europe, or the United Kingdom. This phenomenon may be related to compounding trilostane into packets, which is a common practice among veterinary clinics in Korea. OBJECTIVE: Analyze packets filled by hand and others filled using a semi-automatic packing device for accuracy of trilostane strength. ANIMALS: Medication packets prepared for 3 dogs with preexisting prescriptions for NOH were analyzed. METHOD: A trilostane assay was developed for analysis. Trilostane (Vetoryl) capsules were used as clinical controls. Forty-four medication packets containing trilostane (Vetoryl), prepared by 3 clinicians for 3 dogs with NOH were analyzed. RESULTS: Of 44 trilostane-containing packets, only 40.9% (18 packets) had acceptable strength of trilostane. CONCLUSIONS AND CLINICAL IMPORTANCE: Clinicians should be aware that compounding trilostane into packets fails to consistently provide measured amounts of trilostane, potentially interfering with response to treatment for NOH in dogs.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34114230/