Peer-reviewed veterinary case report
Cystatin C blood test for detecting chronic kidney disease in cats
By Ghys, L F E et al.·Published in Journal of veterinary internal medicine·2016·Department of Medicine and Clinical Biology of Small Animals·View original on PubMed →
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Original publication title: Evaluation of Cystatin C for the Detection of Chronic Kidney Disease in Cats.
- Species:
- cat
Plain-English summary
A group of 90 cats, including 49 with chronic kidney disease (CKD), were tested to see if a new blood marker called cystatin C could help detect kidney problems. The results showed that while cats with CKD had higher levels of cystatin C in their blood and urine, this marker wasn't reliable enough to distinguish between healthy cats and those with kidney issues. The study concluded that cystatin C isn't a good indicator of kidney function in cats, and other tests might be needed for accurate diagnosis.
People also search for: cat kidney disease symptoms · chronic kidney disease in cats · cystatin C test for cats
Abstract
BACKGROUND: Serum cystatin C (sCysC) and urinary cystatin C (uCysC) are potential biomarkers for early detection of chronic kidney disease (CKD) in cats. An in-depth clinical validation is required. OBJECTIVES: To evaluate CysC as a marker for CKD in cats and to compare assay performance of the turbidimetric assay (PETIA) with the previously validated nephelometric assay (PENIA). ANIMALS: Ninety cats were included: 49 CKD and 41 healthy cats. METHODS: Serum CysC and uCysC concentrations were prospectively evaluated in cats with CKD and healthy cats. Based on plasma exo-iohexol clearance test (PexICT), sCysC was evaluated to distinguish normal, borderline, and low GFR. Sensitivity and specificity to detect PexICT < 1.7 mL/min/kg were calculated. Serum CysC results of PENIA and PETIA were correlated with GFR. Statistical analysis was performed using general linear modeling. RESULTS: Cats with CKD had significantly higher mean ± SD sCysC (1.4 ± 0.5 mg/L) (P < .001) and uCysC/urinary creatinine (uCr) (291 ± 411 mg/mol) (P < .001) compared to healthy cats (sCysC 1.0 ± 0.3 and uCysC/uCr 0.32 ± 0.97). UCysC was detected in 35/49 CKD cats. R(2) values between GFR and sCysC or sCr were 0.39 and 0.71, respectively (sCysC or sCr = μ + GFR + ε). Sensitivity and specificity were 22 and 100% for sCysC and 83 and 93% for sCr. Serum CysC could not distinguish healthy from CKD cats, nor normal from borderline or low GFR, in contrast with sCr. CONCLUSION: Serum CysC is not a reliable marker of reduced GFR in cats and uCysC could not be detected in all CKD cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27461722/