Peer-reviewed veterinary case report
Lipoprotein changes in dogs with pancreatic insufficiency compared
By Minamoto, Tomomi et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·Department of Veterinary Small Animal Clinical Sciences (Minamoto, United States·View original on PubMed →
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Original publication title: Evaluation of density gradient ultracentrifugation serum lipoprotein profiles in healthy dogs and dogs with exocrine pancreatic insufficiency.
- Species:
- dog
Plain-English summary
A group of dogs with exocrine pancreatic insufficiency (EPI) were studied to see how their blood fat levels compared to healthy dogs. Some of the EPI dogs were untreated, while others received enzyme supplements to help with digestion. The untreated dogs had more severe issues with their blood fat levels, but those receiving enzyme treatment showed improvements and had blood fat profiles similar to healthy dogs. This suggests that enzyme supplements can help manage blood fat levels in dogs with EPI.
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Abstract
Changes in proportions of lipoprotein classes have been described in disease states in humans. In veterinary medicine, hyperlipidemia can cause complications, such as cutaneous xanthomas, liver disease, cholelithiasis, pancreatitis, glomerular disease, lipemia retinalis, or peripheral neuropathy, but there are few reports regarding lipoproteins in diseased animals. For canine serum, we partially validated continuous lipoprotein density profiling (CLPDP), a novel density gradient ultracentrifugation technique. We examined canine lipoproteins separated by CLPDP by transmission electron microscopy (TEM). We compared lipoprotein profiles between healthy control dogs ( n = 29) and dogs with exocrine pancreatic insufficiency (EPI; n = 28) using CLPDP. Dogs with EPI included those untreated (EPI-NT; n = 6) and those treated with enzyme supplementation (EPI-T; n = 22). Our preliminary assay validation showed that CLPDP was repeatable (CV = 11.2%) and reproducible (CV = 10.6%) in canine serum. The diameters of lipoproteins analyzed by TEM were similar to those reported previously. Dogs in the EPI-NT group had more severe dyslipidemia than dogs in the EPI-T group. Dogs in the EPI-T group had lipoprotein profiles similar to healthy control dogs. CLPDP might be a useful tool for evaluating dyslipidemia in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30175670/