Peer-reviewed veterinary case report
Duodenal changes and immune cells in dogs with treatable gut disease
By Benvenuti, Elena et al.·Published in American journal of veterinary research·2021·View original on PubMed →
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Original publication title: Evaluation of duodenal endoscopic and histologic findings, including counts of forkhead box P3-positive regulatory T cells, in dogs with immunosuppressant-responsive enteropathy.
- Species:
- dog
Plain-English summary
A group of 57 dogs with a condition called immunosuppressant-responsive enteropathy (IRE), which causes gastrointestinal issues, was studied to see how their duodenal (part of the small intestine) health affected their treatment outcomes. The dogs underwent endoscopy and biopsy to assess their condition and were monitored over a year. It was found that dogs with a higher histologic score (3) had worse outcomes, meaning they were less likely to respond to treatment or more likely to relapse. However, the presence of certain immune cells (Foxp3+ Tregs) did not seem to impact their prognosis.
People also search for: dog gastrointestinal issues treatment · dog enteropathy symptoms · dog endoscopy results · dog chronic diarrhea treatment
Abstract
OBJECTIVE: To prospectively evaluate the clinical and prognostic importance of duodenal endoscopic and histologic findings, including duodenal mucosal counts of forkhead box P3-positive regulatory T cells (Foxp3+ Tregs), in dogs with immunosuppressant-responsive enteropathy (IRE). ANIMALS: 57 client-owned dogs with IRE. PROCEDURES: The canine chronic enteropathy clinical activity index (CCECAI) was used to assess each dog when IRE was diagnosed (T0) and 1, 3, 6, and 12 months later. Dogs were grouped on the basis of clinical response (responder group vs nonresponder group) and 12-month long-term outcome (responded to treatment and did not relapse [good outcome group] vs did not respond to treatment or had relapsed [bad outcome group]). At T0, dogs underwent gastrointestinal endoscopy and endoscopic biopsy, with results for variables of duodenal endoscopic and histologic evaluations scored and compared across groups. RESULTS: At T0, the overall median CCECAI score was 7; CCECAI score was not associated with clinical response or relapse. Dogs had significantly greater odds of being in the bad outcome group (vs the good outcome group) if they had a histologic score of 3 (OR, 3.5; 95% CI, 1.09 to 11.3). No differences in the counts of Foxp3+ Tregs were detected between groups. CONCLUSIONS AND CLINICAL RELEVANCE: In dogs with IRE, results indicated that evaluation of Foxp3+ Tregs did not have prognostic value, whereas a duodenal histologic score of 3 could be a negative prognostic factor for response and relapse, and higher severity scores for intraepithelial lymphocytes and lamina propria lymphocytes and plasma cells in duodenal biopsy samples may be negatively associated with response.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33629898/