Peer-reviewed veterinary case report
Evaluation of extended-release diltiazem once daily for cats with hypertrophic cardiomyopathy.
- Journal:
- Journal of the American Animal Hospital Association
- Year:
- 2005
- Authors:
- Wall, Michelle et al.
- Affiliation:
- Department of Small Animal Medicine and Surgery · United States
- Species:
- cat
Abstract
Serum diltiazem concentrations were evaluated following either 30 mg or 60 mg of an extended-release diltiazem administered orally once daily to 13 cats. Sequential blood samples were obtained over 24 hours. Both dosages usually resulted in elevated serum concentrations of >200 ng/mL at 6, 12, 18, and 24 hours. The 30-mg dosage was sometimes associated with low serum concentrations of <50 ng/mL at 18 and 24 hours. The 60-mg dosage (9.3 to 14.8 mg/kg) was associated with lethargy, gastrointestinal disturbances, and weight loss in nine (36%) of 25 client-owned cats. Gastrointestinal disturbances were recognized within 1 week, and weight loss was detected after 2 to 6 months of treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15767652/