Peer-reviewed veterinary case report
Meloxicam and aspirin effects on kidney function in cats with reduced
By Surdyk, Kathryn K et al.·Published in American journal of veterinary research·2013·Department of Physiology and Pharmacology, United States·View original on PubMed →
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Original publication title: Evaluation of glomerular filtration rate in cats with reduced renal mass and administered meloxicam and acetylsalicylic acid.
- Species:
- cat
Plain-English summary
A group of six young adult cats with reduced kidney function and high levels of waste in their blood (azotemia) were treated with either meloxicam (a pain reliever) or acetylsalicylic acid (aspirin) to see if these medications would improve their kidney function. After a week of treatment, the researchers found no significant changes in kidney function measurements, meaning neither medication helped improve how well the kidneys were filtering waste. The cats' kidney function remained stable throughout the study, suggesting that these medications do not affect kidney function in cats with this condition.
People also search for: cat kidney disease treatment · meloxicam for cats · azotemia in cats
Abstract
OBJECTIVE: To determine whether administration of meloxicam or acetylsalicylic acid alters glomerular filtration rate (GFR) in cats with renal azotemia. ANIMALS: 6 young adult cats. PROCEDURES: 3 sexually intact male cats and 3 sexually intact female cats had surgically reduced renal mass and azotemia comparable to International Renal Interest Society chronic kidney disease stages 2 and 3. Renal function was evaluated by measurement of serum creatinine concentration, urinary clearance of exogenously administered creatinine, and the urine protein-to-creatinine concentration ratio (UP:C). Measurements taken in cats receiving placebo at the beginning and end of the study were compared with results obtained at the end of 7 days of treatment with either meloxicam (0.2 mg/kg, SC, on day 1; 0.1 mg/kg, SC, on days 2 to 7) or acetylsalicylic acid (20 mg/kg, PO, on days 1, 4, and 7). RESULTS: No significant treatment effects on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C were detected. Mean ± SEM serum creatinine concentration and urinary clearance of exogenously administered creatinine measurements following 7 days of treatment with meloxicam (serum creatinine concentration, 2.67 ± 0.17 mg/dL; urinary clearance of exogenously administered creatinine, 1.34 ± 0.08 mL/min/kg) and acetylsalicylic acid (serum creatinine concentration, 2.62 ± 0.12 mg/dL; urinary clearance of exogenously administered creatinine, 1.35 ± 0.07 mL/min/kg) were not significantly different from the mean baseline values for these variables (serum creatinine concentration, 2.77 ± 0.14 mg/dL; urinary clearance of exogenously administered creatinine, 1.36 ± 0.07 mL/min/kg). CONCLUSIONS AND CLINICAL RELEVANCE: Neither meloxicam nor acetylsalicylic acid had a measurable effect on urinary clearance of exogenously administered creatinine, serum creatinine concentration, or UP:C. These results are consistent with the hypothesis that GFR of euvolemic cats with normal or reduced renal function is not dependent on cyclooxygenase function.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23531076/