Peer-reviewed veterinary case report
Blood clotting changes in hyperthyroid cats before and after treatment
By Keebaugh, Audrey E et al.·Published in Journal of veterinary internal medicine·2021·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of hemostasis in hyperthyroid cats.
- Species:
- cat
Plain-English summary
A group of 25 hyperthyroid cats was studied to see if they had issues with blood clotting compared to 13 healthy cats. The hyperthyroid cats showed higher levels of certain blood markers, indicating changes in how their blood clots, but they did not have a higher risk of forming dangerous blood clots. After receiving radioactive iodine treatment, which is a common therapy for hyperthyroidism, the blood markers improved significantly. This suggests that treating hyperthyroidism can help normalize blood clotting in affected cats.
People also search for: hyperthyroid cat symptoms · radioactive iodine treatment for cats · cat blood clotting issues
Abstract
BACKGROUND: Hyperthyroid cats might have a predisposition to arterial thrombus formation. The mechanism for thrombogenesis currently is unknown but could be associated with systemic hypercoagulability as seen in hyperthyroid humans. OBJECTIVE: Our purpose was to evaluate markers of hemostasis in hyperthyroid cats compared to healthy cats, and in hyperthyroid cats before and after radioactive iodine treatment (RIT). ANIMALS: Twenty-five cats with hyperthyroidism and 13 healthy euthyroid cats >8 years of age. METHODS: Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen concentration, antithrombin (AT), D-dimers, thrombin-antithrombin complexes (TAT), von Willebrand Factor antigen (vWF : Ag), and activity of factors VIII and IX were measured. An echocardiogram was performed in all cats. Hemostatic markers and echocardiogram were evaluated again 6 to 9 months after successful RIT in 7 cats. RESULTS: Hyperthyroid cats had higher fibrinogen concentration (P < .0001), AT activity (P < .0001), and vWF : Ag concentration (P = .01) than healthy control cats with all results decreasing significantly post-RIT. Hyperthyroid cats were not more likely to be in a hypercoaguable state than euthyroid cats (P = .08). Serum T4 concentration was not a predictor of a hypercoagulable state (P = .53). CONCLUSIONS AND CLINICAL IMPORTANCE: Hyperthyroid cats have evidence of altered hemostasis that does not appear to be solely attributable to cardiac abnormalities, but no evidence of a hypercoagulable state. Findings suggest altered hemostasis resolves after RIT. Hyperthyroid cats could have endothelial dysfunction as indicated by increased vWF : Ag which could potentiate thrombogenesis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34590754/