Peer-reviewed veterinary case report
Hypoxia and iron levels in urine of cats with chronic kidney disease
By Chen, Chien-Hui et al.·Published in Frontiers in veterinary science·2024·School of Veterinary Medicine·View original on PubMed →
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Original publication title: Evaluation of hypoxia-inducible factor-1α and urine non-transferrin-bound iron concentrations in cats with chronic kidney disease.
- Species:
- cat
Plain-English summary
A group of cats with chronic kidney disease (CKD) were studied to understand how certain proteins and iron levels in their urine related to the severity of their condition. Healthy cats had higher levels of a protein called HIF-1α, which decreased in cats with advanced CKD. Additionally, cats with protein in their urine had higher levels of non-transferrin-bound iron, which can cause damage to the kidneys. This research suggests that monitoring these substances could help veterinarians assess kidney health in cats and manage their treatment more effectively.
People also search for: cat chronic kidney disease symptoms · cat protein in urine treatment · cat kidney disease management
Abstract
INTRODUCTION: Hypoxia-inducible factors (HIF) regulate gene transcription, which aids hypoxia adaptation while promoting renal fibrosis. Non-transferrin-bound iron (NTBI) is a catalytic form of iron that can lead to oxidative damage. However, NTBI in cat biofluids has rarely been evaluated. AIMS: We assessed cat plasma and urine HIF-1α (pHIF-1α/uHIF-1α) concentrations and urine NTBI (uNTBI) concentrations to investigate their relationship with chronic kidney disease (CKD) severity. METHODS: pHIF-1α and uHIF-1α concentrations were measured using commercial ELISA kits, while uNTBI concentrations were detected by inductively coupled plasma mass spectrometry. RESULTS: Healthy cats ( = 35) and cats with CKD ( = 84) formed the study cohorts. pHIF-1α concentrations increased from 9.48 pg./mL (median) in the healthy cohort to 11.42 pg./mL in early-stage CKD cats but decreased to 8.50 pg./mL in late-stage CKD cats. uHIF-1α concentrations gradually decreased with a significant difference between the control group (44.61 pg./mL) and the late-stage CKD group (36.79 pg./mL, < 0.001). Cats with proteinuria had significantly higher uNTBI concentrations (35.61 ppb) than non-proteinuric cats (25.13 ppb, = 0.019). Finally, the concentrations of pHIF-1α and uHIF-1α were positively correlated independent of renal function. CONCLUSION AND CLINICAL IMPORTANCE: Overall, pHIF-1α and uHIF-1α concentrations are lower in advanced CKD cats, while uNTBI concentrations are significantly higher in proteinuric cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39748872/