Peer-reviewed veterinary case report
Injectable robenacoxib reduces post-surgery pain in cats
By King, Stephen et al.·Published in BMC veterinary research·2016·Elanco Animal Health, United States·View original on PubMed →
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Original publication title: Evaluation of injectable robenacoxib for the treatment of post-operative pain in cats: results of a randomized, masked, placebo-controlled clinical trial.
- Species:
- cat
Plain-English summary
A group of cats undergoing surgery, including spaying and neutering, received either an injectable pain medication called robenacoxib or a placebo to see which helped with post-operative pain. The cats that received robenacoxib needed less additional pain relief compared to those that got the placebo, showing that the medication was effective in managing pain. Most cats showed improvements in behavior and comfort within the first few hours after surgery, and the treatment was generally well tolerated with few side effects. Overall, robenacoxib proved to be a good option for helping cats recover from surgery without significant complications.
People also search for: cat post-operative pain relief · robenacoxib for cats · spaying cat pain management
Abstract
BACKGROUND: Few pharmaceuticals are registered in cats for the management of post-operative pain and inflammation. The objective of this study was to assess the field efficacy and safety of an injectable formulation of the nonsteroidal anti-inflammatory drug robenacoxib in cats undergoing surgery. The study was a multi-center, prospective, randomized, masked, parallel-group, placebo-controlled clinical trial. A total of 349 cats were enrolled and underwent surgery comprising forelimb onychectomy, as an example of orthopedic surgery, plus either ovariohysterectomy or castration. All cats received butorphanol prior to anesthesia and forelimb four-point regional nerve blocks with bupivacaine after induction of general anesthesia. Cats were randomized to receive daily subcutaneous (s.c.) injection of robenacoxib, at a target dosage of 2.0 mg/kg (n = 174), or placebo (n = 175) once prior to surgery and for an additional two days post-operatively. RESULTS: Significantly (P = 0.037) fewer cats administered robenacoxib received additional analgesia rescue therapy (34 of 173, 19.7 %) compared to cats given placebo (73 of 175, 41.7 %). The percentage of treatment success was therefore 80.3 % with robenacoxib and 58.3 % with placebo. Behavior, posture, pain on palpation of the paw and soft tissue surgery sites, and overall pain were significantly (P < 0.05) improved versus placebo at various time points within the first 8 h in cats receiving robenacoxib. The most frequently reported adverse events were incision site infection/dehiscence, bleeding, vomiting, decreased appetite and lethargy. Frequencies of reported adverse clinical signs, hematology, serum chemistry and urinalysis variables, and body weight changes were similar between groups. There were no significant changes from baseline with robenacoxib in hepatic, hematological or renal clinical pathology variables. CONCLUSIONS: Robenacoxib by s.c. injection was effective and well tolerated in the control of post-operative pain associated with orthopedic, ovariohysterectomy and castration surgery in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27686251/