Peer-reviewed veterinary case report
Stem cell injection tested for chronic kidney disease in cats
By Quimby, Jessica M. et al.·Published in Journal of Feline Medicine and Surgery·2011·Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA, United States·View original on Crossref →
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Original publication title: Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: A pilot study
- Species:
- cat
Plain-English summary
Four cats with chronic kidney disease (CKD) received a special treatment involving injections of their own stem cells into the kidneys to see if it could help improve their condition. After the injections, two of the cats showed some improvement in kidney function and had lower levels of a waste product called creatinine in their blood. The procedure was safe and did not cause any immediate or long-term side effects. However, due to the complexity and number of procedures involved, this treatment may not be practical for widespread use in everyday veterinary care.
People also search for: cat chronic kidney disease treatment · stem cell therapy for cats · improving cat kidney function · cat kidney disease symptoms
Abstract
The feasibility of autologous intrarenal mesenchymal stem cell (MSC) therapy in cats with chronic kidney disease (CKD) was investigated. Six cats (two healthy, four with CKD) received a single unilateral intrarenal injection of autologous bone marrow-derived or adipose tissue-derived MSC (bmMSC or aMSC) via ultrasound guidance. Minimum database and glomerular filtration rate (GFR) via nuclear scintigraphy were determined pre-injection, at 7 days and at 30 days post-injection. Intrarenal injection did not induce immediate or long-term adverse effects. Two cats with CKD that received aMSC experienced modest improvement in GFR and a mild decrease in serum creatinine concentration. Despite the possible benefits of intrarenal MSC injections for CKD cats, the number of sedations and interventions required to implement this approach would likely preclude widespread clinical application. We concluded that MSC could be transferred safely by ultrasound-guided intrarenal injection in cats, but that alternative sources and routes of MSC therapy should be investigated.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/j.jfms.2011.01.005