Peer-reviewed veterinary case report
Stem cell injection tested for chronic kidney disease in cats
By Quimby, Jessica M et al.·Published in Journal of feline medicine and surgery·2011·Department of Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: a pilot study.
- Species:
- cat
Plain-English summary
Four cats with chronic kidney disease (CKD) received a special treatment called mesenchymal stem cell (MSC) injection to see if it could help improve their kidney function. After the injections, two of the cats showed some improvement in their kidney function tests, with better results in their glomerular filtration rate and lower creatinine levels. The procedure was done safely without any immediate or long-term side effects. However, the complexity of the treatment means it may not be practical for regular use in veterinary clinics just yet.
People also search for: cat chronic kidney disease treatment · mesenchymal stem cell therapy for cats · improving cat kidney function · cat kidney disease symptoms
Abstract
The feasibility of autologous intrarenal mesenchymal stem cell (MSC) therapy in cats with chronic kidney disease (CKD) was investigated. Six cats (two healthy, four with CKD) received a single unilateral intrarenal injection of autologous bone marrow-derived or adipose tissue-derived MSC (bmMSC or aMSC) via ultrasound guidance. Minimum database and glomerular filtration rate (GFR) via nuclear scintigraphy were determined pre-injection, at 7 days and at 30 days post-injection. Intrarenal injection did not induce immediate or long-term adverse effects. Two cats with CKD that received aMSC experienced modest improvement in GFR and a mild decrease in serum creatinine concentration. Despite the possible benefits of intrarenal MSC injections for CKD cats, the number of sedations and interventions required to implement this approach would likely preclude widespread clinical application. We concluded that MSC could be transferred safely by ultrasound-guided intrarenal injection in cats, but that alternative sources and routes of MSC therapy should be investigated.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21334237/