Peer-reviewed veterinary case report
Markers linked to prognosis in dog skin mast cell tumors
By Aytemiz Danyer, Işıl & Gürel, Aydın·Published in Acta veterinaria Hungarica·2024·1Ministry of Agriculture and Forestry·View original on PubMed →
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Original publication title: Evaluation of Ki67, Bax, Bcl-2 and KIT in canine cutaneous mast cell tumours and their relationship with histopathology and prognosis.
- Species:
- dog
Plain-English summary
A dog with a skin tumor, specifically a mast cell tumor, was studied to understand how certain tests can help predict how well the dog might do after treatment. Researchers looked at different grading systems and markers in the tumor samples to see how they related to survival rates. They found that certain patterns and levels of specific markers could indicate a better or worse prognosis. For dogs with lower levels of the Bax marker, the median survival time was longer. This information can help veterinarians provide better guidance on treatment options and expected outcomes for dogs with these tumors.
People also search for: dog mast cell tumor prognosis · canine skin tumor treatment · mast cell tumor survival rates
Abstract
Canine cutaneous mast cell tumours (CCMCTs) are common in dogs and exhibit many unpredictable behaviors. This study aimed to encourage pathology laboratories in developing countries to routinely assess prognosis by applying commonly used histopathological grading systems and immunohistochemistry (IHC) markers. We performed histological grading according to both the Patnaik and Kiupel systems, determined the mitotic count (MC) and carried out IHC for the detection of Ki67, Bax, Bcl-2 and KIT in 54 CCMCT cases. MC was associated with both grading systems in terms of survival following diagnosis and prognostic factors differed among cases categorized by the cut-off value of 5. KIT patterns were associated with grading systems and MC. The cohort with pattern II had a lower survival rate than those with patterns I and III. Ki67 was associated with survival when evaluated over the cut-off value of 0.018. Bax expression was associated with both grading systems. Median survival time was longer in patients with lower Bax expression level. Immunohistochemical detection of KIT, Ki67 and Bax improves histopathology in predicting the prognosis. If IHC is unavailable, reports regarding MC and values from both grading systems are the most effective, convenient and cost-effective way to provide the most reliable prognostic data and guidance for the clinicians.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38112689/