Peer-reviewed veterinary case report
Metoclopramide and ranitidine effects on reflux in anesthetized
By Favarato, E S et al.·Published in Research in veterinary science·2012·Department of Veterinary Medicine, Brazil·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of metoclopramide and ranitidine on the prevention of gastroesophageal reflux episodes in anesthetized dogs.
- Species:
- dog
Plain-English summary
Ninety healthy female dogs undergoing surgery were tested to see if two medications, metoclopramide and ranitidine, could prevent stomach acid from flowing back into the esophagus during anesthesia. The dogs were divided into three groups: one received only anesthesia, one got metoclopramide, and the other received ranitidine before surgery. After the procedures, it was found that neither medication significantly reduced the number of dogs that experienced reflux episodes. In total, seven dogs had reflux, indicating that these treatments did not help in this situation.
People also search for: dog reflux during anesthesia · metoclopramide for dogs · ranitidine for dogs before surgery
Abstract
This research aimed to evaluate the effect of metoclopramide and ranitidine in the prevention of gastroesophageal reflux episodes during anesthetic procedures. Ninety healthy female dogs were submitted to elective ovariosalpingohisterectomy, randomly divided into three groups of 30 animals. The control group received only the anesthetic protocol. The metoclopramide group received an intravenous bolus of 1mg/kg, and continuous infusion (1 mg/kg/h intravenously) immediately after anesthetic induction. The ranitidine group received an intravenous bolus of 2 mg/kg, 6 h before anesthesia. Anesthesia (acepromazine, propofol and isofluorane) was standardized and the esophageal pH variations were recorded. Esophagoscopy was carried out after surgery. No difference (p<0.05) was verified in the reflux episodes between the groups. Seven animals presented reflux. Metoclopramide in bolus and continuous infusion, as well as ranitidine, 6 h before anesthesia, did not influence the reduction of the incidence of gastroesophageal reflux.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21864875/