Peer-reviewed veterinary case report
MCM7 protein levels predict survival in dogs with skin mast cell
By Berlato, D et al.·Published in Veterinary and comparative oncology·2012·Oncology Unit, United Kingdom·View original on PubMed →
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Original publication title: Evaluation of minichromosome maintenance protein 7 as a prognostic marker in canine cutaneous mast cell tumours.
- Species:
- dog
Plain-English summary
A study looked at 95 dogs with skin tumors called mast cell tumors (MCTs) to see if a protein marker, MCM7, could help predict how long they might live after diagnosis. The results showed that dogs with a low MCM7 score (0.18 or less) had a much longer survival time, with some living over 10 years, while those with a higher score lived an average of just 187 days. This suggests that checking the MCM7 levels in dogs with MCTs could help veterinarians understand the likely outcome and tailor treatment plans accordingly.
People also search for: dog mast cell tumor prognosis · MCM7 score in dogs · mast cell tumor treatment options
Abstract
Minichromosome maintenance proteins (MCMs) are sensitive markers of cellular proliferation and have been shown to be significant predictors of survival in several human malignancies. MCM7 was evaluated as a prognostic marker in canine cutaneous mast cell tumours (MCTs). MCM7 immunohistochemistry was performed and an index of MCM7-positive cells calculated in dogs with known outcome. The Receiver Operating Characteristics method was used to individuate the best cut-off value of MCM7 score as predictor of survival. Survival analysis and prognostic variables were analysed with statistical methods. Ninety-five dogs were included with 31 dying of MCTs. A value of 0.18 was used as cut-off value of MCM7 score as a binary variable. The median survival time for MCM7 score ≤0.18 was not reached at 3668 days, whereas for MCM7 score >0.18 was 187 days (log-rank test; P < 0.0001). In the multivariable analysis, MCM7 was significantly associated with survival after controlling for age, surgical margins and histological grade (hazard ratio 9.2; P = 0.001).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22235877/