Peer-reviewed veterinary case report
Evaluation of Mycobacterium bovis double knockout mce2-phoP as candidate vaccine against bovine tuberculosis.
- Journal:
- Tuberculosis (Edinburgh, Scotland)
- Year:
- 2015
- Authors:
- García, Elizabeth et al.
- Affiliation:
- Instituto de Biotecnologí
- Species:
- rodent
Abstract
In this study, a Mycobacterium bovis knockout strain in phoP-phoR and mce2 operons was tested as an antituberculosis experimental vaccine in animal models. The double mutant strain was significantly more attenuated than the wild type strain in inmunocompetent and inmunodeficient mice. Vaccination with the double mutant protected mice against challenge with a virulent M. bovis strain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25620706/