Peer-reviewed veterinary case report
Oral Bravecto kills tick nymphs on dogs effectively
By Allen, Kelly et al.·Published in Parasites & vectors·2020·Department of Veterinary Pathobiology, United States·View original on PubMed →
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Original publication title: Evaluation of oral fluralaner (Bravecto) for efficacy against nymphs of Amblyomma americanum and Rhipicephalus sanguineus (sensu lato).
- Species:
- dog
Plain-English summary
Ten dogs were given a single dose of oral fluralaner (Bravecto) to see how well it worked against ticks that can feed on them and spread diseases. The treatment was very effective, killing over 90% of the nymphs from two types of ticks, Amblyomma americanum and Rhipicephalus sanguineus, for up to 12 weeks. Even when some ticks were still alive after 48 hours, the treatment still showed strong results, especially against those that had attached and fed. This means that Bravecto can be a reliable option for keeping your dog safe from these ticks.
People also search for: dog tick prevention · Bravecto for dogs · how long does Bravecto last · dog tick treatment · Amblyomma americanum control
Abstract
BACKGROUND: Amblyomma americanum and Rhipicephalus sanguineus (sensu lato) nymphs commonly feed on and transmit pathogens to dogs (Canis familiaris). Control of immature and adult tick life stages is necessary to fully protect animals. We evaluated efficacy of oral fluralaner (Bravecto) against induced infestations with A. americanum and R. sanguineus (s.l.) nymphs on dogs in two experiments. METHODS: In each experiment, 10 dogs were administered oral fluralaner chewable tablets one time on Day 0 at a targeted minimum dose of 25 mg/kg body weight and 10 dogs remained non-treated controls. Dogs were infested with two groups of 50 A. americanum nymphs and two groups of 50 R. sanguineus (s.l.) nymphs on Days -1, 6, 28, 56 and 84. At 48 h and 72 h post-infestation, nymphs were collected from dogs, assessed as live or dead, and enumerated into categories defining attachment and engorgement status. Fluralaner efficacy was determined in separate analyses against all live nymphs and against live-fed nymphs, i.e. live nymphs that were attached to dogs at the time of collection and/or were engorged. Fluralaner was considered effective when mean numbers of live ticks were reduced in fluralaner-treated dogs by ≥ 90%. RESULTS: Fluralaner efficacy against all live and live-fed A. americanum nymphs in the first experiment was > 94% on all collection days. Efficacy against all live R. sanguineus (s.l.) nymphs in the first experiment was  > 96% on all collection days  excluding the 48 h counts for infestations on Days 28 (83.7%), 56 (82.9%) and 84 (86.7%); efficacy against live-fed R. sanguineus (s.l.) nymphs was > 95% on all 48 h/72 h count days. Fluralaner efficacy against all live A. americanum nymphs in the second experiment was > 93% on all collection days for 8 weeks excluding the 48 h count for infestation on Day 56 (87.8%); efficacy against live-fed A. americanum nymphs was > 91% on all count days for 8 weeks. Efficacy against all live R. sanguineus (s.l.) nymphs in the  second experiment was > 91% on all 72 h collection days  except for infestations on Days 28 (76.8%) and 56 (86.3%); efficacy against live-fed R. sanguineus (s.l.) nymphs was 100% on all 72 h count days. CONCLUSIONS: A single administration of oral fluralaner to dogs is effective against A. americanum and R. sanguineus (s.l.) nymphs for up to 12 weeks.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32552774/