Peer-reviewed veterinary case report
Ivermectin given by mouth to dogs for flea and tick control
By Magalhães, Viviane S et al.·Published in Veterinary parasitology·2016·Animal Parasitology Department, Brazil·View original on PubMed →
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Original publication title: Evaluation of pharmacokinetics and efficacy of ivermectin following oral administration in dogs against experimental infection of Ctenocephalides felis felis and Rhipicephalus sanguineus.
- Species:
- dog
Plain-English summary
A group of dogs was given an oral dose of ivermectin to see how well it worked against fleas and ticks. While the medication was absorbed well into their systems, it only effectively reduced the flea population by 67% and the tick population by 35%. This suggests that while ivermectin is commonly used for various treatments in dogs, it may not be the best choice for controlling these specific parasites. Pet owners should consider other options for flea and tick prevention.
People also search for: dog flea treatment · ivermectin for dogs · how to control ticks in dogs
Abstract
With the increasing number of pets in home the human-animal relationship is increasingly close and care about control disease growing. Ivermectin (IVM) is frequently used because its proven safety. IVM is recommended for the treatment of demodectic scabies and prevention of heartworm in dogs, but informally is extremely used to control of Ctenocephalides felis felis and Rhipicephalus sanguineus. The aim of this study is evaluate the use of IVM in dogs, by the oral route at 0.6μg/kg dose, against experimental infection of these parasites using the construction of the plasma concentration curve and efficacy study. A IVM quantification method in canine plasma using HPLC-FL was developed and validated based on RE n°899/03 ANVISA. The samples collected during the efficacy test was analyzed by this validated method and prove Cof 350ng/mL at 4h (t) and AUC of 8411ng/h/mL. Spite of formulation have shown good absorption, the highest efficiency values found for Rhipcephalus sanguineus and Ctenocephalides felis felis were very low, 35% and 67% respectively, demonstrating this not be the most appropriate treatment for the control of these parasites.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27692320/