Peer-reviewed veterinary case report
Plasma and urine test for silent mitral valve disease in dogs
By Rasmussen, Caroline E et al.Ā·Published in Veterinary journal (London, England : 1997)Ā·2010Ā·Department of Basic Animal and Veterinary SciencesĀ·View original on PubMed ā
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Original publication title: Evaluation of plasma and urinary levels of 6-keto-prostaglandin F1alpha as a marker for asymptomatic myxomatous mitral valve disease in dogs.
- Species:
- dog
Plain-English summary
A group of Cairn terriers and other breeds were tested for levels of a substance called 6-keto-prostaglandin F1alpha, which may indicate heart health, particularly in dogs with a heart condition known as myxomatous mitral valve disease (MMVD). The researchers found that the levels of this substance were higher in Cairn terriers compared to other dogs, but there was no clear link between these levels and the severity of MMVD in dogs that showed no symptoms. This suggests that the levels of 6-keto-PGF(1alpha) might be more related to the breed rather than the presence of heart disease in these asymptomatic dogs.
People also search for: dog heart disease symptoms Ā· Cairn terrier heart problems Ā· myxomatous mitral valve disease in dogs
Abstract
Endothelial dysfunction might be involved in the pathogenesis of myxomatous mitral valve disease (MMVD). The aims of this study were (1) to validate an enzyme immunoassay (EIA) for canine 6-keto-prostaglandin (PG)F(1alpha) (prostacyclin metabolite and marker for endothelial function) and (2) to compare plasma and urinary 6-keto-PGF(1alpha) in dogs with asymptomatic MMVD. The study included two breeds predisposed to MMVD and two control groups (Cairn terriers and dogs of different breeds). Echocardiography was used to estimate the severity of MMVD. The intra- and inter-assay coefficients of variation were between 3.1% and 24.5% in the assay range. No echocardiographic parameter was correlated with plasma or urinary 6-keto-PGF(1alpha) (P>0.05), but all control dogs had lower urinary 6-keto-PGF(1alpha) (P<0.02) and the Cairn terriers had higher plasma 6-keto-PGF(1alpha) (P<0.02). The EIA appeared valid for measuring canine 6-keto-PGF(1alpha) in plasma and urine. It is suggested that 6-keto-PGF(1alpha) levels are related to breed and not MMVD in asymptomatic stages.
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Search related cases āOriginal publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19324577/