Peer-reviewed veterinary case report
Blood pressure response to norepinephrine in dogs with induced
By Martínez, Nivia I et al.·Published in Research in veterinary science·2005·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of pressor sensitivity to norepinephrine infusion in dogs with iatrogenic hyperadrenocorticism. Pressor sensitivity in dogs with hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of dogs with iatrogenic hyperadrenocorticism (a condition caused by excessive steroid treatment) showed severe hypertension (high blood pressure) when given norepinephrine, a medication that raises blood pressure. In this study, eight dogs with this condition were compared to eight healthy dogs. The dogs with hyperadrenocorticism had a much stronger reaction to the norepinephrine, leading to dangerously high blood pressure levels in seven of them. This suggests that dogs with this condition are more sensitive to medications that affect blood pressure.
People also search for: dog high blood pressure treatment · iatrogenic hyperadrenocorticism in dogs · norepinephrine effects on dogs
Abstract
Hypertension is a common complication of canine hyperadrenocorticism. Increased pressor sensitivity to endogenous catecholamines is currently believed to be the main mechanism involved in the development of hypertension in human hyperadrenocorticism. The aim of this study was to evaluate pressor sensitivity to norepinephrine in dogs after induction of iatrogenic hyperadrenocorticism (I-HAC) by serial arterial blood pressure measurements during infusions of increasing dose rates of norepinephrine (0.1, 0.15, 0.2, 0.3, 0.4, 0.6, and 0.8 microg/kg/min) in eight dogs with I-HAC and eight control dogs. Systolic, diastolic, mean blood pressure and heart rate measurements were recorded. The changes in these parameters between the two groups of dogs were compared. Dogs in the I-HAC group had a more pronounced pressor response to norepinephrine infusions than control dogs since the infusions had to be stopped in seven of the dogs due to severe hypertension (>240 mmHg). The mean maximum tolerated dose rate in the control group was 0.6 microg/kg/min with a standard error of 0.0 and 0.34 microg/kg/min with a standard error of 0.08 in the I-HAC group. The study demonstrated the presence of increased pressor sensitivity to norepinephrine in dogs with I-HAC.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15500836/