Peer-reviewed veterinary case report
Outcome factors for dogs with multiple skin mast cell tumors
By Mullins, Marie N et al.·Published in Journal of the American Veterinary Medical Association·2006·Animal Cancer Center and Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of prognostic factors associated with outcome in dogs with multiple cutaneous mast cell tumors treated with surgery with and without adjuvant treatment: 54 cases (1998-2004).
- Species:
- dog
Plain-English summary
A group of 54 dogs with multiple skin tumors called mast cell tumors (MCTs) underwent surgery to remove them, with some receiving additional treatments afterward. The study found that most dogs had a good chance of long-term survival, with 87% surviving for at least a year and 85% for 2 to 5 years. Factors that could negatively impact survival included incomplete removal of the tumors, larger tumor size, and showing clinical signs at diagnosis. However, if the tumors were completely excised, the dogs had a low chance of the cancer spreading and a generally positive outlook.
People also search for: dog mast cell tumor treatment · dog skin tumor prognosis · multiple mast cell tumors in dogs · dog surgery for skin tumors · mast cell tumor survival rates
Abstract
OBJECTIVE: To evaluate prognostic factors associated with outcome of dogs with multiple cutaneous mast cell tumors (MCTs) treated with surgery with or without adjuvant treatment. DESIGN: Retrospective case series. ANIMALS: 54 dogs with a minimum of 2 simultaneous, histologically confirmed cutaneous MCTs that had been excised and had adequate staging and follow-up data. PROCEDURE: Medical records from 1998 to 2004 were examined. Outcome was assessed with the Kaplan-Meier product-limit method and log-rank analysis. Prognostic factors evaluated included signalment; number, histologic grade, location, size, local recurrence, and de novo development of MCTs; quality of surgical margins; clinical signs at the time of diagnosis; and use of adjuvant treatment. RESULTS: Medical records of 54 dogs with 153 tumors were included. Median follow-up time was 658 days. Median disease-free interval (1,917 days; range, 11 to 1,917 days) and median survival time (1,917 days; range, 14 to 1,917 days) were not yet reached. The 1- year and 2- to 5-year survival rates were 87% and 85%, respectively. The overall rate of metastasis was 15%. Factors that negatively influenced survival time in the univariate analysis included incomplete excision, local recurrence, size > 3 cm, clinical signs at the time of diagnosis, and use of adjuvant treatment. Presence of clinical signs at the time of diagnosis was the only negative prognostic factor for disease-free interval detected in the multivariate analysis. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that multiple cutaneous MCTs in dogs are associated with a low rate of metastasis and a good prognosis for long-term survival with adequate excision of all MCTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16426175/