Peer-reviewed veterinary case report
Red blood cell changes in dogs with heartworm disease
By Kim, Su-Jung et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2020·Changbaig Hyun Animal Special Clinic, South Korea·View original on PubMed →
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Original publication title: Evaluation of red blood cell profiles in dogs with heartworm disease.
- Species:
- dog
Plain-English summary
A group of 86 dogs with heartworm disease (HWD) showed signs of anemia, which means they had fewer red blood cells than normal. The study found that dogs with severe symptoms and pulmonary hypertension (high blood pressure in the lungs) had significantly lower red blood cell counts and higher variability in their red blood cell sizes compared to healthy dogs. This suggests that monitoring red blood cell profiles can help veterinarians track the severity of heartworm disease in dogs. Treatment for heartworm disease typically involves medications to kill the worms and supportive care for any complications like anemia.
People also search for: dog heartworm disease symptoms · anemia in dogs treatment · how to treat heartworm in dogs
Abstract
Recent studies have found that anemia and anisocytosis are precipitating factors for certain heart diseases in dogs. This study evaluated the prevalence and correlation of anemia and red blood cell distribution width (RDW) in dogs with heartworm disease (HWD). The study population consisted of 20 healthy control dogs and 86 dogs with HWD: 28 dogs with no clinical signs or pulmonary hypertension (Group 1), 42 dogs with mild clinical signs but no pulmonary hypertension (Group 2), and 16 dogs with severe clinical signs and pulmonary hypertension (Group 3). Along with echocardiographic interrogation of pulmonary hypertension, red blood cell (RBC) profiles were evaluated, including RDW. The total number of red blood cells (tRBCs), hematocrit (HCT), and hemoglobin (HGB) concentration was significantly lower in Group 3 dogs compared to control dogs (< 0.05), while the RDW was significantly higher in Group 3 dogs than in control dogs (< 0.05). The RDW was closely correlated to other RBC profiles and the presence of pulmonary hypertension (< 0.05). The severity of tricuspid regurgitant gradient (TRG) was closely correlated with Hb and tRBC (< 0.05), but not with the RDW and reticulocyte count. This study finding indicated that anemia and anisocytosis are common complications in dogs with severe clinical signs and pulmonary hypertension caused by heartworm disease (HWD). It would therefore be beneficial for clinicians to routinely check red blood cell (RBC) profiles, including RDW, in order to monitor the progression of heartworm disease in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33012975/