Peer-reviewed veterinary case report
Right heart function and galectin-3 levels in dogs with pulmonary
By Winter, Randolph L et al.·Published in Journal of veterinary internal medicine·2023·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Evaluation of right ventricular diastolic function, systolic function, and circulating galectin-3 concentrations in dogs with pulmonary stenosis.
- Species:
- dog
Plain-English summary
A group of 30 dogs with pulmonary stenosis (PS), a heart condition that affects blood flow, showed signs of right ventricular (RV) dysfunction during tests. Their heart function was measured using echocardiography, which revealed that both the diastolic (when the heart fills with blood) and systolic (when the heart pumps blood) functions were impaired compared to healthy dogs. Additionally, levels of galectin-3, a marker for heart muscle damage, were significantly higher in the dogs with PS. These findings suggest that dogs with this condition may have heart muscle changes that could affect their treatment and management.
People also search for: dog pulmonary stenosis symptoms · heart problems in dogs · elevated galectin-3 in dogs · dog heart function tests
Abstract
BACKGROUND: Cardiovascular diseases with increased right ventricular (RV) afterload induce RV diastolic and systolic dysfunction, and myocardial fibrosis in humans. Studies in dogs with pulmonary stenosis (PS) evaluating RV diastolic function and markers of myocardial fibrosis are lacking. HYPOTHESIS/OBJECTIVES: Dogs with PS have echocardiographic evidence of RV diastolic and systolic dysfunction and increased serum concentrations of galectin-3 (Gal-3), a surrogate biomarker for myocardial fibrosis. ANIMALS: Forty client-owned dogs (10 controls, 30 with PS). METHODS: Prospective study. All dogs had systemic blood pressure measurement, serum biochemical analysis, echocardiography, and measurement of serum Gal-3 concentration performed. RESULTS: Variables of RV diastolic function were obtained in 39/40 dogs. Trans-tricuspid flow velocity in early diastole to trans-tricuspid flow velocity in late diastole ratios (RV E/A) were lower (P < .001) in dogs with PS (median, 0.94; range, 0.62-2.04) compared to controls (1.78; 1.17-2.35). Trans-tricuspid flow velocity in early diastole to tricuspid annular myocardial velocity in early diastole ratios (RV E/e') were higher (P < .001) in dogs with PS (11.55; 4.69-28) compared to control (6.21; 5.16-7.21). Variables of RV systolic function were lower in dogs with PS (P = <.001). Serum Gal-3 concentration was higher (P = .002) in dogs with PS (285.1 pg/mL; 94.71-406.97) compared to control dogs (162.83 pg/mL; 52.3-232.82). CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with PS have RV diastolic and systolic dysfunction, and increased Gal-3 concentrations. These findings suggest the presence of RV myocardial fibrosis in dogs with PS, which could impact clinical management.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37767953/