Peer-reviewed veterinary case report
Stem cell and gel treatment for dog thigh bone repair safety
By Ma, Zihang et al.·Published in Frontiers in veterinary science·2023·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Evaluation of safety and efficacy of the bone marrow mesenchymal stem cell and gelatin-nano-hydroxyapatite combination in canine femoral defect repair.
- Species:
- dog
Plain-English summary
A dog with a femoral shaft fracture, a common type of bone injury, was treated using a combination of bone marrow stem cells and a special gel-like material. The treatment aimed to help the bone heal better by allowing the stem cells to attach and grow in the area of the fracture. After just four weeks, the combination treatment showed significant improvement in bone growth, and by eight weeks, the healing was even more pronounced. This approach proved to be safe and effective in promoting bone repair in dogs with similar injuries.
People also search for: dog femoral fracture treatment · stem cell therapy for dogs · bone healing in dogs
Abstract
Femoral shaft fracture is a common bone trauma in dogs. The limitation of mesenchymal stem cells in bone defect applications is that the cell suspension cannot be fixed to the bone defect site. In the study, our objective was to substantiate the combined application of canine bone marrow mesenchymal stem cells (cBMSCs) and gelatin-nano-hydroxyapatite (Gel-nHAP) and evaluate its therapeutic effect on bone defect diseases in dogs. Experiments were performed to evaluate the following: (1) the porosity of Gel-nHAP; (2) the adhesion of cBMSCs to Gel-nHAP; and (3) the effect of Gel-nHAP on cBMSC proliferation. The efficacy and safety of the combination of cBMSC and Gel-nHAP in the repair of femoral shaft defects were evaluated in animal experiments. The results showed that Gel-nHAP supported the attachment of cBMSCs and exhibited good biocompatibility. In the animal bone defect repair experiment, significant cortical bone growth was observed in the Gel-nHAP group at week 8 ( < 0.05) and in the cBMSCs-Gel-nHAP group at week 4 ( < 0.01). We demonstrated that Gel-nHAP could promote the repair of bone defects, and the effect of cBMSC-Gel-nHAP on the repair of bone defects was profound.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37415965/