Peer-reviewed veterinary case report
Cytokine gene activity in dogs with lymphocytic-plasmacytic colitis
By Tamura, Yu et al.·Published in The Journal of veterinary medical science·2014·Department of Veterinary Clinical Sciences, Japan·View original on PubMed →
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Original publication title: Evaluation of selected cytokine gene expression in colonic mucosa from dogs with idiopathic lymphocytic-plasmacytic colitis.
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) known as lymphocytic-plasmacytic colitis (LPC) was studied to understand the role of certain immune system proteins called cytokines in their condition. Researchers looked at the levels of various cytokines in the dogs' colon tissues but found that most of them did not show significant differences compared to healthy dogs, except for one specific cytokine, IL-23. This suggests that the immune response in dogs with LPC may not be as distinct as in humans with similar bowel issues. The findings could help veterinarians better understand and treat this common digestive problem in dogs.
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Abstract
Lymphocytic-plasmacytic colitis (LPC) is a common form of inflammatory bowel disease (IBD) affecting the canine large intestine. Cytokines are thought to be involved in the pathogenesis of IBD. However, to date, few studies have investigated cytokine mRNA expression in dogs with LPC. In this study, we investigated mRNA transcription levels of T helper cell cytokines, such as IFN-γ, IL-4, IL-17 and IL-10 and pro-inflammatory cytokines, such as IL-1β, IL-6, TNF-α, IL-8, IL-12 and IL-23, in colonic mucosa from LPC dogs by quantitative real-time RT-PCR. No significant differences were detected in cytokine mRNA expressions between dogs with LPC and controls, except for IL-23p19. Dogs with LPC failed to express a predominant cytokine profile in inflamed colonic mucosa as opposed to human IBD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24976586/