Peer-reviewed veterinary case report
Serum 17-hydroxyprogesterone test for diagnosing dog Cushing's disease
By Benitah, Noémi et al.·Published in Journal of the American Veterinary Medical Association·2005·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
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Original publication title: Evaluation of serum 17-hydroxyprogesterone concentration after administration of ACTH in dogs with hyperadrenocorticism.
- Species:
- dog
Plain-English summary
A group of 110 dogs was tested to see if measuring a hormone called 17-hydroxyprogesterone (17-OHP) after giving an ACTH injection could help diagnose hyperadrenocorticism, a condition where the body produces too much cortisol. In healthy dogs, reference hormone levels were established, while 53 dogs with hyperadrenocorticism showed abnormal hormone levels after the ACTH test. The results indicated that measuring 17-OHP could be a helpful tool for vets when other tests are unclear. This could lead to better diagnosis and treatment for dogs suffering from this condition.
People also search for: dog hyperadrenocorticism symptoms · ACTH test for dogs · 17-hydroxyprogesterone in dogs
Abstract
OBJECTIVE: To evaluate serum 17-hydroxyprogesterone (17-OHP) concentration measurement after administration of ACTH for use in the diagnosis of hyperadrenocorticism in dogs. DESIGN: Prospective study. ANIMALS: 110 dogs. PROCEDURE: Serum 17-OHP concentrations were measured before and after ACTH stimulation in 53 healthy dogs to establish reference values for this study. Affected dogs had pituitary-dependent (n = 40) or adrenal tumor-associated (12) hyperadrenocorticism or potentially had atypical hyperadrenocorticism (5; diagnosis confirmed in 1 dog). In affected dogs, frequency interval and borderline and abnormal serum 17-OHP concentrations after ACTH stimulation were determined. Serum cortisol concentrations were assessed via low-dose dexamethasone suppression and ACTH stimulation tests. RESULTS: In healthy dogs, serum 17-OHP concentration frequency intervals were grouped by sex and reproductive status (defined as < 95th percentile). Frequency intervals of serum 17-OHP concentrations after ACTH stimulation were < 77, < 2.0, < 3.2, and < 3.4 ng/mL (< 23.3, < 6.1, < 9.7, and < 10.3 nmol/L) for sexually intact and neutered females and sexually intact and neutered males, respectively. In 53 dogs with confirmed hyperadrenocorticism, serum cortisol concentrations after ACTH stimulation and 8 hours after administration of dexamethasone and serum 17-OHP concentrations after ACTH stimulation were considered borderline or abnormal in 79%, 93%, and 69% of dogs, respectively. Two of 5 dogs considered to have atypical hyperadrenocorticism had abnormal serum 17-OHP concentrations after ACTH stimulation. CONCLUSIONS AND CLINICAL RELEVANCE: Serum 17-OHP concentration measurement after ACTH stimulation may be useful in the diagnosis of hyperadrenocorticism in dogs when other test results are equivocal.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16220669/