Peer-reviewed veterinary case report
Acute phase protein levels in dogs with circumanal gland tumors
By Lisiecka, U et al.·Published in Journal of comparative pathology·2019·Department of Epizootiology and Clinic of Infectious Diseases·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Evaluation of Serum Acute Phase Protein Concentrations in Dogs with Circumanal Gland Tumours.
- Species:
- dog
Plain-English summary
A group of 39 male mixed-breed dogs with circumanal gland tumors (tumors near the anus) were studied to see how certain proteins in their blood changed during treatment. In dogs with benign tumors, the levels of these proteins decreased with therapy, indicating improvement. However, in dogs with malignant tumors, the protein levels increased even after treatment, suggesting a poor response. This research indicates that measuring these proteins could help vets determine the severity of the tumors and monitor treatment effectiveness, potentially guiding future care decisions.
People also search for: dog circumanal gland tumor treatment · dog tumor blood test · dog cancer prognosis markers
Abstract
The aim of this study was to determine the serum concentrations of acute phase proteins (APPs), including C-reactive protein (CRP), serum amyloid A (SAA) and haptoglobin (Hp) in dogs with circumanal gland tumours. Investigations were conducted on 39 male dogs of mixed breed. The animals were divided into four groups depending on the degree of tumour malignancy and type of hormones that were dominant in the bloodstream. All measurements of serum APPs were conducted by the use of commercial diagnostic kits. In dogs with benign tumours, the concentrations of each APP decreased during therapy, while in dogs with malignant tumours, despite anti-tumour therapy, concentrations of APPs in serum increased markedly. The results of this study suggest that changes in serum concentrations of CRP, SAA and Hp during anti-hormone therapy may be a reliable marker for differentiating tumour grade and degree of malignancy. Including APPs in routine diagnostics may assist with formulating a prognosis for the outcome of the disease, before implementing anti-tumour therapy. Moreover, monitoring the effectiveness of therapy may be possible based on the determination of serum APP concentrations.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31540620/