Peer-reviewed veterinary case report
Serum Apolipoprotein A1 Levels in Dogs with Sepsis
By Massimo Giunti et al.·Published in Frontiers in Veterinary Science·2020·View original on DOAJ →
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Original publication title: Evaluation of Serum Apolipoprotein A1 in Canine Sepsis
- Species:
- dog
Plain-English summary
A group of dogs with sepsis, including those with conditions like parvoviral enteritis and septic peritonitis, were studied to see how serum apolipoprotein A1 (Apo-A1) levels related to their health outcomes. The results showed that dogs with septic peritonitis had significantly lower Apo-A1 levels compared to healthy dogs, and those with lower levels of Apo-A1 were more likely to not survive. The study suggests that measuring Apo-A1 could help veterinarians diagnose septic peritonitis and predict which dogs might have a worse outcome. More research is needed to confirm these findings.
People also search for: dog sepsis symptoms · low Apo-A1 in dogs · septic peritonitis treatment in dogs
Abstract
Decreased serum apolipoprotein A1 (Apo-A1) concentration is associated with mortality in human sepsis. The diagnostic and prognostic role of serum Apo-A1 concentrations in canine sepsis was evaluated. Serum samples from septic dogs (n = 91) and healthy controls (n = 15) were retrospectively analyzed. According to the sepsis origin, four categories were identified: parvoviral enteritis (n = 26), pyometra (n = 20), septic peritonitis (n = 19), and miscellanea (n = 26). The canine acute patient physiologic and laboratory evaluation fast score (APPLEfast), serum C-reactive protein (CRP) and albumin concentrations were reviewed in all enrolled dogs. Increased CRP (252.6 ± 119.2 mg/L; Reference Interval: 0–8.5 mg/L) and significant lower serum albumin and Apo-A1 concentrations were documented in dogs with sepsis (22.8 ± 5.3 g/L and 1.17 ± 0.27 g/L, respectively) compared to healthy ones (33.1 ± 2.5 g/L and 1.32 ± 0.05 g/L, respectively) (P < 0.0001). According to the origin of sepsis, only the subgroup of dogs with septic peritonitis had significantly lower Apo-A1 (1.03 ± 0.26 g/L) concentrations compared to healthy dogs (P < 0.001). No significant differences were found in serum albumin and CRP concentrations, and in APPLEfast score values among the different subgroups of sepsis. Diagnosis of septic peritonitis was associated with a higher frequency of death (P = 0.006). In septic dogs, significant lower Apo-A1 concentrations were detected in non-survivors (1.02 ± 0.28 g/L; n = 27) compared to survivors (1.23 ± 0.24 g/L; n = 64; P = 0.0007). Moreover, significant higher values of the APPLEfast score were calculated in non-survivors (26 ± 4; n = 19) compared to survivors (23 ± 4; n = 51) (P = 0.0114). According to the area under the ROC curve analysis, Apo-A1 <96 mg/dl had a fair accuracy (AUC = 0.72) to correctly predict mortality (P = 0.0004). Apo-A1 might support a diagnosis of canine septic peritonitis with a potential prognostic significance. Further prospective studies are warranted.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2020.00263