Peer-reviewed veterinary case report
Serum apolipoprotein A1 levels in dogs with sepsis
By Giunti, Massimo et al.·Published in Frontiers in veterinary science·2020·Department of Veterinary Medical Sciences, Italy·View original on PubMed →
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Original publication title: Evaluation of Serum Apolipoprotein A1 in Canine Sepsis.
- Species:
- dog
Plain-English summary
A group of dogs with sepsis, including those with parvoviral enteritis and septic peritonitis, were studied to see how a protein called apolipoprotein A1 (Apo-A1) could help predict their chances of survival. The researchers found that dogs with septic peritonitis had lower levels of Apo-A1 compared to healthy dogs, and those with very low levels of Apo-A1 were more likely to not survive. The study suggests that measuring Apo-A1 could be useful for diagnosing septic peritonitis and understanding the severity of the condition. More research is needed to confirm these findings and improve treatment options for affected dogs.
People also search for: dog sepsis symptoms · low apolipoprotein A1 in dogs · septic peritonitis treatment in dogs
Abstract
Decreased serum apolipoprotein A1 (Apo-A1) concentration is associated with mortality in human sepsis. The diagnostic and prognostic role of serum Apo-A1 concentrations in canine sepsis was evaluated. Serum samples from septic dogs (= 91) and healthy controls (= 15) were retrospectively analyzed. According to the sepsis origin, four categories were identified: parvoviral enteritis (= 26), pyometra (= 20), septic peritonitis (= 19), and miscellanea (= 26). The canine acute patient physiologic and laboratory evaluation fast score (APPLE), serum C-reactive protein (CRP) and albumin concentrations were reviewed in all enrolled dogs. Increased CRP (252.6 ± 119.2 mg/L; Reference Interval: 0-8.5 mg/L) and significant lower serum albumin and Apo-A1 concentrations were documented in dogs with sepsis (22.8 ± 5.3 g/L and 1.17 ± 0.27 g/L, respectively) compared to healthy ones (33.1 ± 2.5 g/L and 1.32 ± 0.05 g/L, respectively) (< 0.0001). According to the origin of sepsis, only the subgroup of dogs with septic peritonitis had significantly lower Apo-A1 (1.03 ± 0.26 g/L) concentrations compared to healthy dogs (< 0.001). No significant differences were found in serum albumin and CRP concentrations, and in APPLEscore values among the different subgroups of sepsis. Diagnosis of septic peritonitis was associated with a higher frequency of death (= 0.006). In septic dogs, significant lower Apo-A1 concentrations were detected in non-survivors (1.02 ± 0.28 g/L;= 27) compared to survivors (1.23 ± 0.24 g/L;= 64;= 0.0007). Moreover, significant higher values of the APPLEscore were calculated in non-survivors (26 ± 4;= 19) compared to survivors (23 ± 4;= 51) (= 0.0114). According to the area under the ROC curve analysis, Apo-A1 <96 mg/dl had a fair accuracy (AUC = 0.72) to correctly predict mortality (= 0.0004). Apo-A1 might support a diagnosis of canine septic peritonitis with a potential prognostic significance. Further prospective studies are warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32478112/