Peer-reviewed veterinary case report
Blood test for osteoarthritis in dogs with hip dysplasia
By Nganvongpanit, Korakot et al.·Published in Journal of veterinary science·2008·Department of Veterinary Preclinical Science·View original on PubMed →
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Original publication title: Evaluation of serum chondroitin sulfate and hyaluronan: biomarkers for osteoarthritis in canine hip dysplasia.
- Species:
- dog
Plain-English summary
A group of dogs with hip dysplasia (a common joint problem) had their blood tested to see if certain substances in their serum could indicate osteoarthritis (a type of joint disease). The study found that dogs with hip dysplasia had higher levels of one type of chondroitin sulfate but lower levels of another type and hyaluronan compared to healthy dogs. This suggests that measuring these substances in the blood could help veterinarians diagnose osteoarthritis in dogs with hip dysplasia.
People also search for: dog hip dysplasia symptoms · osteoarthritis treatment for dogs · chondroitin sulfate for dogs arthritis
Abstract
Hip dysplasia (HD) is one of the most important bone and joint diseases in dogs. Making the radiographic diagnosis is sometime possible when the disease has markedly progressed. Chondroitin sulfate (CS) and hyaluronan (HA) are the most important cartilage biomolecules that are elevated in the serum taken from dogs with osteoarthritis. The serum CS and HA can be detected by an ELISA technique, with using monoclonal antibodies against CS epitope 3B3 and WF6 and the HA chain as the primary antibodies. The aim of this study was to compare the levels of serum CS (both epitopes) and HA in non-HD and HD dogs. All 123 dogs were categorized into 2 groups. The non-HD group was composed of 98 healthy dogs, while the HD group was comprised of 25 HD dogs. Blood samples were collected for analyzing the serum CS and HA levels with using the ELISA technique. The results showed that the average serum level of the CS epitope WF6 in the HD group (2,594 +/- 3,036.10 ng/ml) was significantly higher than that in the non-HD group (465 +/- 208.97 ng/ml) (p < 0.01) while the epitope 3B3 in the HD group (105 +/- 100.05 ng/ml) was significantly lower than that in the non-HD group (136 +/- 142.03 ng/ml) (p < 0.05). The amount of serum HA in the HD group (134.74 +/- 59.71 ng/ml) was lower than that in the non HD group (245.45 +/- 97.84 ng/ml) (p < 0.05). The results indicate that the serum CS and HA levels might be used as biomarkers for osteoarthritis in HD dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18716453/