Peer-reviewed veterinary case report
Blood histone levels and survival in dogs with acute pancreatitis
By Nivy, Ran et al.·Published in American journal of veterinary research·2021·Veterinary Teaching Hospital and Koret School of Veterinary Medicine·View original on PubMed →
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Original publication title: Evaluation of serum histone concentrations and their associations with hemostasis, markers of inflammation, and outcome in dogs with naturally occurring acute pancreatitis.
- Species:
- dog
Plain-English summary
A group of 29 dogs with acute pancreatitis was studied to see how certain blood markers related to their recovery. The researchers looked at levels of histones and inflammatory markers, but found that these did not help predict which dogs would survive their hospital stay. However, they did notice that dogs who did not survive had more severe symptoms, like jaundice and changes in blood clotting tests. The study suggests that while some blood tests might not be useful for predicting outcomes, other clinical signs could be important for understanding the severity of pancreatitis in dogs.
People also search for: dog pancreatitis symptoms · dog jaundice treatment · acute pancreatitis in dogs recovery
Abstract
OBJECTIVE: To compare serum concentrations of histones and inflammatory markers in dogs with acute pancreatitis and healthy control dogs, investigate associations of these variables with coagulation test results and survival (vs nonsurvival) to hospital discharge, and examine the prognostic utility of clinical findings and routine laboratory and coagulation tests in affected dogs. ANIMALS: 36 dogs. PROCEDURES: Dogs with findings consistent with acute pancreatitis (n = 29) and healthy control dogs (7) were enrolled in a prospective, observational study. Serum concentrations of histones, interleukin (IL)-6, and tumor-necrosis factor-α were assessed for all dogs. Clinical (including ultrasonographic) findings, relevant history, routine laboratory and coagulation test results, and outcomes were recorded for dogs with pancreatitis. Variables were assessed to determine an association with outcome for affected dogs and hospitalization time for survivors; histone concentrations and markers of inflammation were compared among survivors, nonsurvivors, and controls. Correlation between quantitative variables was investigated. RESULTS: Serum histone and IL-6 concentrations did not differentiate survivors (n = 23) from nonsurvivors (6); IL-6 concentrations in affected dogs were correlated with 1,2-o-dilauryl-rac-glycero glutaric acid-(6'-methylresorufin) ester lipase activity (= 0.436) and hospitalization time (= 0.528). Pancreatitis-associated peritoneal fluid, obtundation, and jaundice were more common, and serum bilirubin concentration, serum alanine aminotransferase and aspartate aminotransferase activities, and prothrombin and activated partial thromboplastin times were greater in nonsurvivors than in survivors. Thromboelastometric changes consistent with hypercoagulability were detected in survivors; hypocoagulability was detected in 2 nonsurvivors. CONCLUSIONS AND CLINICAL RELEVANCE: Serum histone concentrations were not associated with presence of acute pancreatitis or outcome for affected dogs. Further research is needed to investigate the clinical and therapeutic implications of hypocoagulability, hepatocellular injury, and pancreatitis-associated peritoneal fluid in affected dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34432516/