Peer-reviewed veterinary case report
Serum thymidine kinase 1 predicts treatment and relapse in dogs
By Boyé, Pierre et al.·Published in Journal of veterinary internal medicine·2019·Department of Medical Oncology, France·View original on PubMed →
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Original publication title: Evaluation of serum thymidine kinase 1 activity as a biomarker for treatment effectiveness and prediction of relapse in dogs with non-Hodgkin lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with lymphoma were monitored for a specific blood marker called serum thymidine kinase 1 (sTK1) to see if it could help predict how well they were responding to treatment and if their cancer might come back. The study found that dogs who had a complete response to treatment had much lower levels of sTK1 compared to those with only a partial response. Additionally, if a dog's sTK1 levels increased significantly after treatment, it could indicate that the lymphoma was returning. This information could help veterinarians better manage treatment and monitor for relapses in dogs with lymphoma.
People also search for: dog lymphoma treatment response · sTK1 levels in dogs · predicting cancer relapse in dogs
Abstract
BACKGROUND: Serum thymidine kinase 1 (sTK1) activity is closely correlated with DNA synthesis. OBJECTIVES: Evaluate sTK1 activity as a biomarker for treatment response and early detection of relapse in dogs with lymphoma. ANIMALS: Ninety-seven client-owned dogs with naive or relapsed lymphoma and 23 healthy dogs. METHODS: Prospective study. Serum TK1 activity measured by refined ELISA-based method (DiviTum assay, Biovica International) before treatment, at clinical response, and every 4 weeks until relapse or last follow-up. RESULTS: Serum TK1 activity was ≤20 Du/L in 96% (22/23) of healthy dogs. Pretreatment sTK1 activity was >20 Du/L in 88% (85/97) dogs with lymphoma. At clinical response, sTK1 activity was significantly lower in dogs with complete (CR, n = 36) versus partial (PR, n = 29) response (P < .0001). Sensitivity (Se) and specificity (Sp) of sTK1 activity for detecting nonfully responders were 76% and 100%, respectively, with cutoff of 119.5 Du/L (AUC, 0.90; 95%-CI, 0.81-0.98; P < .0001). In dogs with CR, a 5-fold increase in sTK1 activity at a 4-week interval predicted relapse at the subsequent 4-week assessment with a Se 50% and Sp 94% (AUC, 0.72; 95%-CI, 0.55-0.90; P = .02). An increase of sTK1 activity (>2.7-fold value measured at clinical response) predicted relapse at subsequent 4-week assessment with a Se 61% and Sp 88% (AUC, 0.79; 95%-CI, 0.64-0.95; P = .004). CONCLUSIONS AND CLINICAL IMPORTANCE: Monitoring sTK1 activity could help to detect complete responders and early disease progression in dogs with lymphoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31129922/