Peer-reviewed veterinary case report
Sperm DNA damage and vitamin C-E treatment in fertile and subfertile
By Lopes-Santiago, B V et al.·Published in Reproduction in domestic animals = Zuchthygiene·2012·Faculdade de Medicina Veteriná, Brazil·View original on PubMed →
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Original publication title: Evaluation of sperm DNA peroxidation in fertile and subfertile dogs.
- Species:
- dog
Plain-English summary
A group of dogs, including both fertile and subfertile ones, were given daily supplements of vitamin C and E for 60 days to see if it would improve their sperm health. The study involved eleven dogs, with some having normal sperm counts and others showing signs of infertility, like low sperm count or abnormal sperm. After the treatment, tests showed no significant changes in the DNA quality of the sperm for either group. This suggests that the antioxidant supplements did not help improve sperm health in these dogs.
People also search for: dog infertility treatment · vitamin C and E for dog sperm health · why is my dog not getting pregnant
Abstract
Oxidative stress (OS) has been recognized as one of the most important causes of male infertility. The antioxidant activities of seminal plasma and epididymal fluid are not enough to prevent OS, which can damage sperm membranes and DNA, so antioxidant supplementation has been used as a treatment of male infertility. The aim of this experiment was to evaluate the DNA peroxidation before and after antioxidant supplementation with vitamin C and E in dogs with and without fertility problems. A total of eleven dogs were used and were divided in two groups: fertile group (G1), dogs with normal spermiogram (n = 5); subfertile group (G2): dogs with low sperm count (<20 × 10(6) sptz/ml) and/or more than 30% of total sperm pathology (n = 6). Both groups received 500 mg/day of vitamin C and 500 mg/day of vitamin E for 60 days. A semen sample was collected before (M1) and after (M2) oral supplementation. Samples were analysed for DNA peroxidation by measuring the 8-hydroxy-2'-deoxyguanosine concentration. No significant difference was observed between groups at either time. Oral supplementation with 500 mg/day of vitamin C and 500 mg/day of vitamin E did not change the DNA peroxidation in fertile and subfertile dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23279501/