Peer-reviewed veterinary case report
Apomorphine injection under skin or vein to make dogs vomit compared
By Fischer, Christiana et al.·Published in Journal of the American Veterinary Medical Association·2021·View original on PubMed →
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Original publication title: Evaluation of subcutaneous versus intravenous administration of apomorphine for induction of emesis in dogs.
- Species:
- dog
Plain-English summary
A group of 42 dogs that needed to vomit due to ingestion of something harmful were given a medication called apomorphine either under the skin (subcutaneous) or directly into the vein (intravenous). Both methods were effective, with about 80% of the dogs vomiting after receiving the medication. However, the dogs that received the IV treatment started to vomit much faster, usually within just a couple of minutes, compared to those who received it under the skin, who took about 13.5 minutes. Both methods had similar side effects, making either option a reliable choice for inducing vomiting in dogs.
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Abstract
OBJECTIVE: To prospectively compare the effectiveness and any adverse effects of apomorphine administered SC or IV for induction of emesis in dogs. ANIMALS: 42 client-owned dogs. PROCEDURES: Dogs for which emesis induction was deemed appropriate by the attending clinician were prospectively randomized to receive apomorphine (0.03 mg/kg [0.01 mg/lb]) either SC (n = 20) or IV (22). Data collected included whether emesis was successfully induced, time from drug administration to emesis, number of emetic events, and adverse events (eg, sedation, protracted vomiting, or other). RESULTS: Of the 20 dogs given apomorphine SC, 16 (80%) vomited. Of the 22 dogs given apomorphine IV, 18 (82%) vomited. With regard to route of administration, the number of dogs in which emesis was induced did not differ significantly. Median time to the first emetic event was 13.5 minutes (range, 3 to 32 minutes) in the SC treatment group and 2 minutes (range, 1 to 5 minutes) in the IV treatment group; the difference was significant. There was no significant difference in the number of emetic events or frequency of adverse events between the 2 groups. CONCLUSIONS AND CLINICAL RELEVANCE: Apomorphine administered SC or IV reliably induced emesis in dogs. Compared with SC administration of apomorphine, the time from drug administration to emesis associated with IV administration was significantly shorter, a finding that has clinical importance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34242075/