Peer-reviewed veterinary case report
Kidney effects of eye drops flurbiprofen and diclofenac in healthy
By Lanuza, Rick et al.·Published in Veterinary ophthalmology·2016·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of systemic absorption and renal effects of topical ophthalmic flurbiprofen and diclofenac in healthy cats.
- Species:
- cat
Plain-English summary
Twelve healthy domestic shorthair cats were given eye drops containing either flurbiprofen or diclofenac four times a day for two weeks to see how much of the medication entered their bloodstream and if it affected their kidneys. Both medications were absorbed into the cats' systems, with flurbiprofen showing higher levels in the blood than diclofenac. Fortunately, there were no significant kidney issues detected after the treatment, meaning the cats remained healthy overall. This study suggests that while these eye drops are effective, they don't harm kidney function in healthy cats.
People also search for: cat eye drops flurbiprofen · diclofenac for cats · cat kidney health after medication
Abstract
OBJECTIVE: To investigate systemic absorption and renal effects of topically applied ophthalmic flurbiprofen and diclofenac in healthy cats. ANIMALS STUDIED: Twelve domestic shorthair cats. PROCEDURES: Cats were randomly assigned to two treatment groups (n = 6) and administered one drop (approximately 40 μL) of either flurbiprofen 0.03% or diclofenac 0.1% in both eyes four times daily (6 am, 12 pm, 6 pm, and 12 am) for 14 days. Blood samples were collected on days 0, 4, 8, 14, 16, and 17 and analyzed by liquid chromatography and mass spectrometry for flurbiprofen and diclofenac plasma concentrations. A complete blood count (CBC), serum chemistry, and urinalysis were analyzed at the beginning of the study (Day 0) and at the end of topical drug administration (Day 15). RESULTS: Both drugs demonstrated systemic absorption. Flurbiprofen was detected (mean ± SD) at day 4 (237 ± 65 ng/mL), day 8 (396 ± 91 ng/mL), day 14 (423 ± 56 ng/mL), day 16 (350 ± 66 ng/mL), and day 17 (270 ± 62 ng/mL), and diclofenac was detected (mean ± SD) at day 4 (130 ± 44 ng/mL), day 8 (131 ± 25 ng/mL), day 14 (150 ± 36 ng/mL), and sporadically on day 16 [corrected]. Flurbiprofen plasma concentration decreased slowly over 48 h after the last dose. No clinically significant abnormalities were noted in the serum blood urea nitrogen, creatinine, or urine specific gravity at the end of topical drug administration compared to the beginning of the study. CONCLUSIONS: Flurbiprofen and diclofenac were systemically absorbed after topical administration four times daily to both eyes of healthy cats. Flurbiprofen reached higher plasma concentrations compared to diclofenac.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26119523/