Peer-reviewed veterinary case report
T-cell activity in the duodenum of dogs with skin food allergies
By Veenhof, Eveline Z et al.·Published in American journal of veterinary research·2010·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Evaluation of T-cell activation in the duodenum of dogs with cutaneous food hypersensitivity.
- Species:
- dog
Plain-English summary
A group of dogs with skin problems caused by food allergies were studied to see if there were any immune reactions in their intestines. Eleven dogs with these skin issues and eight healthy dogs were compared, but researchers found that the immune responses in the intestines were similar in both groups. Even though the dogs' skin symptoms improved after changing their diet, there were no changes in the immune cells in their intestines. This suggests that the gut may not be the main area where the immune system reacts to food allergies that cause skin problems.
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Abstract
OBJECTIVE: To determine whether skin-related clinical signs in cutaneous food hypersensitivity (CFH) coincide with immune reactivity in the intestine in dogs. ANIMALS: 11 dogs with CFH without intestinal clinical signs and 8 healthy control dogs. PROCEDURES: After a provocation and elimination diet, the duodenal gene expression levels of Th1-, Th2- and Treg-related cytokines and transcription factors were investigated by means of quantitative PCR assay. The presence of CD3(+), CD8(+), CD4(+), CD1c(+), gammadelta T-cell receptor(+), and major histocompatibility complex II(+) cells in duodenal epithelium and lamina propria were determined. RESULTS: The expression of Th1-, Th2-, and Treg-related genes in dogs with CFH and healthy control dogs was similar. Although clinical signs disappeared, there was no effect of the elimination diet on cytokines, transcription factors, or cellular phenotypes. CONCLUSIONS AND CLINICAL RELEVANCE: No change in T-cell phenotypes or a distinct Th1, Th2, or Treg profile was detected in the duodenum of dogs with only cutaneous clinical signs of food hypersensitivity. This suggested that the intestinal mucosa is not the primary site of T-cell activation that eventually leads to cutaneous food hypersensitivity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20367052/