Peer-reviewed veterinary case report
Side effects of oral firocoxib in healthy dogs after 28 days
By Steagall, P V M et al.·Published in Journal of veterinary pharmacology and therapeutics·2007·School of Veterinary Medicine and Animal Science, Brazil·View original on PubMed →
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Original publication title: Evaluation of the adverse effects of oral firocoxib in healthy dogs.
- Species:
- dog
Plain-English summary
A group of six healthy dogs were given a medication called firocoxib to see if it caused any side effects. Over 28 days, the dogs were monitored for changes in their blood counts, organ function, and gastrointestinal health, but none showed any adverse effects. Tests before and after treatment showed no significant changes, and all dogs remained healthy throughout the study. This suggests that firocoxib is well tolerated in dogs without causing harmful effects.
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Abstract
This study evaluated the adverse effects of oral firocoxib in dogs. Six dogs (20.2+/-6.3 kg) were studied. Values for complete blood count (CBC), serum urea, creatinine, alanine transaminase, alanine phosphatase, gamma-glutamyl transferase, occult blood in feces, platelet aggregation, and buccal mucosal bleeding time were measured before and 7, 14, 21, and 29 days after SID treatment with firocoxib 5.3+/-0.34 mg/kg (FG) or lactose 1 mg/kg (LG) for 28 days, in a randomized crossover study. Gastrointestinal (GI) tract endoscopy was performed before treatment began and at 29 days. Lesions were scored from grade 0 to 6. Data were analyzed using anova and paired t-tests (P<0.05). None of the dogs presented adverse clinical effects. There were no significant changes in CBC, biochemical profiles within groups, or differences between groups. Pretreatment mean+/-SD bleeding time (LG, 70.7+/-32.1 sec; FG, 75.8+/-38.1 sec) and platelet aggregation (LG, 86.4+/-10.2%; FG, 85.6+/-9.2%) were not significantly different from readings at 29 days (LG, 95.2+/-25 sec; FG, 91.7+/-24 sec and LG, 73.2+/-15.1%; FG, 84+/-10.3%) nor the groups were different. None of the dogs had positive fecal occult blood tests, and endoscopic lesion scores were grade 0 both before treatment and at 29 days. Administration of firocoxib did not cause any adverse effects on GI, or hematological or serum biochemical variables and appears to have been well tolerated by dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17472653/