Peer-reviewed veterinary case report
Pain relief after spay surgery in cats: grapiprant vs robenacoxib
By Pisack, Elizabeth K et al.·Published in Journal of feline medicine and surgery·2024·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Evaluation of the analgesic efficacy of grapiprant compared with robenacoxib in cats undergoing elective ovariohysterectomy in a prospective, randomized, masked, non-inferiority clinical trial.
- Species:
- cat
Plain-English summary
A group of 37 female cats, aged 4 months to 10 years, underwent surgery to remove their ovaries and uterus (ovariohysterectomy) and were given either grapiprant or robenacoxib to manage pain afterward. Both medications were effective at reducing pain, as measured by various pain scales, and there was no significant difference in pain relief between the two treatments. Cats showed signs of pain relief shortly after surgery, but their pain levels returned to baseline after about four hours. This study suggests that grapiprant is a good alternative to robenacoxib for managing pain in cats after this type of surgery.
People also search for: cat pain relief after surgery · grapiprant for cats · robenacoxib for cat surgery pain
Abstract
OBJECTIVES: The main objective of this study was to compare the postoperative analgesic effects of grapiprant with those of robenacoxib in cats undergoing ovariohysterectomy (OVH). METHODS: In total, 37 female cats (age range 4 months-10 years, weighing ⩾2.5 kg) were enrolled in a prospective, randomized, masked, non-inferiority (NI) clinical trial. Cats received oral robenacoxib (1 mg/kg) or grapiprant (2 mg/kg) 2 h before OVH. Analgesia was assessed via the Feline Grimace Scale (FGS), the Glasgow Composite Measure Pain Scale-Feline (CMPS-F), von Frey monofilaments (vFFs) and pressure algometry (ALG) 2 h before treatment administration, at extubation, and 2, 4, 6, 8, 18 and 24 hours after extubation. Hydromorphone (<8 h postoperatively) or buprenorphine (>18 h postoperatively) were administered to cats with scores of ⩾5/20 on CMPS-F and/or ⩾4/10 on FGS. NI margins for CMPS-F and vFFs were set at 3 and -0.2, respectively. A mixed-effect ANOVA was used for FGS scores ( <0.05). Data are reported as mean ± SEM. RESULTS: The data from 33 cats were analyzed. The upper limit of the 95% confidence interval (CI) (0.35) was less than the NI margin of 3 for CMPS-F, and the lower limit of the 95% CI (0.055) was greater than the NI margin of -0.2 for vFFs, indicating NI of grapiprant. The FGS scores were greater than baseline at extubation for both treatments (1.65 ± 0.63; = 0.001); however, there was no difference between treatments. There was no difference between treatments, nor treatment by time interaction, for vFFs ( <0.001). The CMPS-F scores for both treatments were higher at extubation but returned to baseline after 4 h ( <0.001). For ALG, there was no difference in treatment or treatment by time interaction. The robenacoxib group had lower pressure readings at extubation and 6 h compared with baseline. CONCLUSIONS AND RELEVANCE: These results indicate that grapiprant was non-inferior to robenacoxib for mitigating postsurgical pain in cats after OVH performed via ventral celiotomy. The impact of grapiprant for analgesia in OVH via the flank is unknown.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38511293/