Peer-reviewed veterinary case report
Colistin treatment effects in dogs with natural endotoxin shock
By Sentürk, S·Published in Journal of veterinary pharmacology and therapeutics·2005·Department of Internal Medicine·View original on PubMed →
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Original publication title: Evaluation of the anti-endotoxic effects of polymyxin-E (colistin) in dogs with naturally occurred endotoxic shock.
- Species:
- dog
Plain-English summary
A group of 30 dogs suffering from endotoxic shock, a serious condition caused by bacterial toxins, were treated to see if a medication called polymyxin-E (colistin) could help. Half of the dogs received colistin along with an antibiotic, while the other half only got the antibiotic. The dogs treated with colistin showed significant improvements, including better hydration and faster recovery of their blood circulation within 24 hours. The study concluded that colistin is effective and safe for treating dogs with this serious condition.
People also search for: dog endotoxic shock treatment · colistin for dogs · dog dehydration symptoms
Abstract
Endotoxin is a potent stimulator of the inflammatory response and is believed to initiate the pathology in gram-negative sepsis. Agents are being searched for that bind and neutralize or block the effects of endotoxin. The aim was to study the anti-endotoxic effects of polymyxin-E (colistin) in endotoxaemic dogs. The study included a total of 30 endotoxaemic dogs, which were divided into two groups (control = 15; test = 15) of both sexes, different breeds and ages. Hetastarch colloid solution (Expahes,10 mL/kg, i.v.) with lactated Ringer's solution (20 mL/kg, i.v., Q12 h) was given to all dogs. While ampicillin was administered (Alfasilin, 10 mg/kg, i.m., Q12 h) as an antibacterial to the control group, colistin (12,500 IU/kg, i.m., Q12 h) + ampicillin were administered to the test group. The clinical examination (body temperature, pulse and respiration rates, capillary filling times, peripheral pulse qualities, dehydration degrees), hematological and biochemical examinations (WBC, RBC, HGB, HCT, thrombocyte, serum urea, creatinine and TNF-alpha) were performed both before the treatment, and 2, 4, 12 and 24 h after the treatment. In comparison with the control group, it was observed that test group had shorter capillary filling time at 24 h (P < 0.001). Moreover, the degree of dehydration in test group, was significantly improved at 24 h (P < 0.01). While the differences in peripheral pulse qualities significantly differed between 0 and 2 h in controls, at 2, 4, 24 h after treatment it was found to be significantly increased when compared with 0 h in the test group. Serum TNF-alpha concentrations were statistically decreased in the test group between 0 h and other times (P < 0.01). When compared with controls, serum TNF-alpha concentrations were lower at 2, 4, 12 and 24 h in test group (P < 0.05). Results of the study indicated that polymyxin-E (colistin) has an anti-endotoxic effect and is safe for the dogs with endotoxemia at the dosage used in this study.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15720516/