Peer-reviewed veterinary case report
Advantix spot-on repels and kills sand flies on dogs for a month
By Bouhsira, Emilie et al.·Published in Parasites & vectors·2018·Ecole Nationale Vé, France·View original on PubMed →
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Original publication title: Evaluation of the anti-feeding and insecticidal effects of a topically administered combination of imidacloprid and permethrin (Advantix®) against Phlebotomus (Larroussius) perniciosus (Newstead, 1911) in dogs following monthly administration.
- Species:
- dog
Plain-English summary
A group of dogs was treated with a topical product called Advantix, which contains imidacloprid and permethrin, to see how well it could repel and kill sand flies. The dogs showed a strong response, with the treatment providing over 88% effectiveness in keeping the flies away and killing them after just one month. The results were consistent even after the second month of treatment, and no side effects were reported. This means that Advantix is a safe and effective option for protecting dogs from sand flies.
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Abstract
BACKGROUND: Two laboratory experiments (Studies 1 and 2) were conducted to confirm the efficacy of an imidacloprid and permethrin combination (Advantix® Spot-on, Bayer) to repel and kill Phlebotomus (Larroussius) perniciosus sand flies when applied once a month topically to dogs. METHODS: Both studies compared dogs treated with a combination containing 100 mg/ml imidacloprid + 500 mg/ml permethrin (Advantix® Spot-on, Bayer) to placebo treated dogs. The treatments were applied topically on Day -28 (Study 2) and Day 0 (Studies 1 and 2). Sand fly exposures with 80 unfed females were performed before the first treatment for allocation purposes and post-treatment on study days (SDs) 1, 7, 14, 21 and 28 (following first or second monthly treatment for Studies 1 and 2, respectively). After 60 min, sand flies were assessed for mortality and engorgement status. RESULTS: Repellent evaluation (anti-feeding effect) on all days post-infestation showed efficacies that ranged between 88.1-99.3% during the first month and 92.2-98.9% during the second. Analyses of the comparison of fed sand fly counts for each treatment group resulted in a highly significant reduction (P < 0.0001) at all post-infestation time points for those dogs treated with Advantix®. A significant (P < 0.0001 for all time points) insecticidal effect was equally demonstrated. No treatment related adverse events were observed during the study. CONCLUSIONS: In the present studies Advantix® Spot-on demonstrated to be safe and to provide excellent four-week sand fly (P. perniciosus) repellency of ≥88.1% and ≥92.2% after a first and second monthly treatment, respectively. A significant insecticidal effect was also observed.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29499732/